Restoring aging-related tissue homeostasis via reactivated innate immunotherapy

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Restoring aging-related tissue homeostasis via reactivated innate immunotherapy"


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A chimeric peptide designed to recruit immune cells has been shown to enhance the ‘coupling’ between senescent cells and natural killer cells to promote immune clearance of senescent cells


for restoration of tissue homeostasis in liver fibrosis, lung injury, cancer and even natural aging in mice. Access through your institution Buy or subscribe This is a preview of


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Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL


ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * National Research Council. _Grand Challenges of Our Aging Society:


Workshop Summary_ (The National Academies Press, 2010). A REVIEW THAT PRESENTS CHALLENGES AND OPPORTUNITIES OF AGING FOR SOCIETIES AROUND THE GLOBE. * López-Otín, C., Blasco, M. A.,


Partridge, L., Serrano, M. & Kroemer, G. Hallmarks of aging: an expanding universe. _Cell_ 186, 243–278 (2023). A REVIEW THAT COMPILES THE 12 HALLMARKS OF AGING. Article  PubMed  Google


Scholar  * Suryadevara, V. et al. SenNet recommendations for detecting senescent cells in different tissues. _Nat. Rev. Mol. Cell Bio._ 25, 1001–1023 (2024). A REVIEW THAT PROVIDES


RECOMMENDATIONS FOR DETECTING SENESCENT CELLS IN DIFFERENT TISSUES IN MICE AND HUMANS. Article  CAS  Google Scholar  * Zhang, B. et al. B cell-derived GABA elicits IL-10+ macrophages to


limit anti-tumour immunity. _Nature_ 599, 471–476 (2021). A PAPER THAT REPORTS THAT SMALL METABOLITES DERIVED FROM B-LINEAGE CELLS HAVE IMMUNOREGULATORY FUNCTIONS. Article  CAS  PubMed 


PubMed Central  Google Scholar  * Amor, C. et al. Senolytic CAR T cells reverse senescence-associated pathologies. _Nature_ 583, 127–132 (2020). A PAPER THAT IDENTIFIES UPAR AS A


CELL-SURFACE PROTEIN THAT IS INDUCED DURING SENESCENCE. Article  CAS  PubMed  PubMed Central  Google Scholar  Download references ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature


remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. THIS IS A SUMMARY OF: Ming, X. et al. A chimeric peptide promotes immune surveillance


of senescent cells in injury, fibrosis, tumorigenesis and aging. _Nat. Aging_ https://doi.org/10.1038/s43587-024-00782-1 (2024). RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS


ARTICLE CITE THIS ARTICLE Restoring aging-related tissue homeostasis via reactivated innate immunotherapy. _Nat Aging_ 5, 17–18 (2025). https://doi.org/10.1038/s43587-024-00782-1 Download


citation * Published: 02 January 2025 * Issue Date: January 2025 * DOI: https://doi.org/10.1038/s43587-024-00782-1 SHARE THIS ARTICLE Anyone you share the following link with will be able to


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