Utx regulates accumulation of lipids via kidney serine

Access through your institution Buy or subscribe Ectopic lipid accumulation in the kidney and liver promotes organ injury and dysfunction. Now, Ling Zheng, Kun Huang and colleagues report a

new regulatory pathway that modulates lipid accumulation in the kidney and liver by controlling serine production in the kidney. Analysis of existing kidney disease gene expression datasets

suggested a potential link between UTX and 3-phosphoglycerate dehydrogenase (PHGDH), which is a rate-limiting enzyme in the synthesis of serine. Compared with healthy individuals, patients

with obesity or diabetic kidney disease had lower levels of _PHGDH_ in their kidneys. Accordingly, the researchers found that serum serine levels were lower in patients with obesity-related

kidney disease and correlated positively with estimated glomerular filtration rate. By contrast, the kidneys of UTX-deficient mice fed an HFD had significantly higher levels of PHGDH protein

(but not mRNA) and serine than controls. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other

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et al. Renal UTX–PHGDH–serine axis regulates metabolic disorders in the kidney and liver. _Nat. Commun._ 13, 3835 (2022) Article  CAS  Google Scholar  Download references AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * Nature Reviews Nephrology http://www.nature.com/nrneph Monica Wang Authors * Monica Wang View author publications You can also search for this author inPubMed 

Google Scholar CORRESPONDING AUTHOR Correspondence to Monica Wang. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wang, M. UTX regulates accumulation of

lipids via kidney serine. _Nat Rev Nephrol_ 18, 543 (2022). https://doi.org/10.1038/s41581-022-00615-7 Download citation * Published: 26 July 2022 * Issue Date: September 2022 * DOI:

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