The study of apoptotic cells by flow cytometry

ABSTRACT Programmed cell death (PCD) is of fundamental importance in the normal development of an animal. It also plays a key role in tumour and radiation biology. PCD produces a sequence of

changes occurring in cells called apoptosis. The main elements of this apoptotic cascade are rapidly being elucidated. Flow cytometry has been used to follow many of these changes. It has

also been used to quantify the number of apoptotic cells in a culture and, more recently, in clinical samples. In this review, the properties of apoptotic cells and the main features of the

apoptotic cascade are described. How flow cytometry can be used to follow changes during the apoptotic cascade is then discussed. Access through your institution Buy or subscribe This is a

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IN A SINGLE POPULATION Article Open access 04 March 2025 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * 34 Wray Park Road, Reigate, RH2 ODE, UK MG Ormerod Authors * MG Ormerod View author

publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ormerod, M. The study of

apoptotic cells by flow cytometry. _Leukemia_ 12, 1013–1025 (1998). https://doi.org/10.1038/sj.leu.2401061 Download citation * Received: 12 January 1998 * Accepted: 10 February 1998 *

Published: 24 July 1998 * Issue Date: 01 July 1998 * DOI: https://doi.org/10.1038/sj.leu.2401061 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

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KEYWORDS * apoptotis: flow cytometry