Long-term effects of untreated leptin deficiency

Access through your institution Buy or subscribe Deficiencies in leptin signalling cause severe early-onset obesity due to hyperphagia. A new study has investigated the long-term clinical

outcomes for children with leptin signalling deficiency who do not receive treatment for the condition. This retrospective cross-sectional study included 145 children from the Punjab region

of Pakistan, with recruitment beginning in 2012. The children all had mutations that caused deficiency of leptin, leptin receptor or melanocortin 4 receptor. Physical, clinical and metabolic

evaluations were conducted. The children with leptin or leptin receptor deficiency tended to have more severe hyperphagia and earlier onset of excessive weight gain than the children with

melanocortin 4 receptor deficiency. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature

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calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Saeed, S. et

al. High morbidity and mortality in children with untreated congenital deficiency of leptin or its receptor. _Cell Rep. Med._ https://doi.org/10.1016/j.xcrm.2023.101187 (2023) Article 

PubMed  PubMed Central  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Endocrinology http://www.nature.com/nrendo/ Claire Greenhill Authors

* Claire Greenhill View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Claire Greenhill. RIGHTS AND PERMISSIONS

Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Greenhill, C. Long-term effects of untreated leptin deficiency. _Nat Rev Endocrinol_ 19, 620 (2023).

https://doi.org/10.1038/s41574-023-00902-8 Download citation * Published: 11 September 2023 * Issue Date: November 2023 * DOI: https://doi.org/10.1038/s41574-023-00902-8 SHARE THIS ARTICLE

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