Mechanism revealed for celastrol’s effects on weight

Access through your institution Buy or subscribe The researchers administered celastrol once daily for 6 days to mice with high-fat diet (HFD)-induced obesity and chow-fed mice that were not

obese. They confirmed previous findings that celastrol results in reduced body weight, fat mass and lean mass in both groups of mice. They also demonstrated that celastrol reduced food

intake in the HFD-fed mice, and a small reduction in food intake was also seen in the chow-fed mice. Next, the researchers treated chow-fed leptin receptor-deficient 8-week-old mice (Lepdb)

and 14-week-old leptin-deficient mice (Lepob) with celastrol. Body weight, fat mass and lean mass were unaffected in these mice, but decreased body weight, fat mass and lean mass were seen

in wild-type controls that were fed chow and were treated with celastrol. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your

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REFERENCES ORIGINAL ARTICLE * Pfuhlmann, K. et al. Celastrol induced weight loss is driven by hypophagia and independent from UCP1. _Diabetes_ https://doi.org/10.2337/db18-0146 (2018)

Article  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Endocrinology http://www.nature.com/nrendo/ Claire Greenhill Authors *

Claire Greenhill View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Claire Greenhill. RIGHTS AND PERMISSIONS Reprints

and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Greenhill, C. Mechanism revealed for celastrol’s effects on weight. _Nat Rev Endocrinol_ 14, 626 (2018).

https://doi.org/10.1038/s41574-018-0102-5 Download citation * Published: 27 September 2018 * Issue Date: November 2018 * DOI: https://doi.org/10.1038/s41574-018-0102-5 SHARE THIS ARTICLE

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