Retraction note: tumour microenvironment programming by an rna–rna-binding protein complex creates a druggable vulnerability in idh-wild-type glioblastoma

Retraction to: _Nature Cell Biology_ (2024) 26:1003-1018 https://doi.org/10.1038/s41556-024-01428-5 The authors are retracting this Article after concerns over several image irregularities

were brought to our attention, including but not limited to the following: * In Fig. 1f, there appears to be a partial overlap between the Control siRNA and WWTR1-AS1 siRNA panels; * In Fig.

6b, the WT-KO and KO-WT mice appear very similar; * In Fig. 6d, there appears to be a partial overlap between the WT-KO and KO-WT panels; * In Fig. 7a, the leftmost images under GMB192 and

GMB925 appear very similar; * In Fig 7d, there appears to be partial overlap between all four panels; * In Fig. 7f, panels 4 and 6 in Week 3 - DHX inhibitor + TMZ appear very similar; * In

Extended Data Fig. 6h, the images under DMSO and DHX inhibitor appear very similar; * In Extended Data Fig. 8d panel PE-A and Extended Data Fig 8e, panel WT-KO, appear very similar. The

authors attribute image overlap and similarities to human error. Given the number of errors, however, they have lost confidence in the reliability of the study and therefore wish to retract

the Article. The authors deeply regret these errors and sincerely apologise to the community. All authors agree to this retraction. AUTHOR INFORMATION Author notes * These authors

contributed equally: Lele Wu, Zheng Zhao, Yong Jae Shin, Yiyun Yin. * These authors jointly supervised this work: Tao Jiang, Vinay Tergaonkar. AUTHORS AND AFFILIATIONS * Laboratory of NFκB

Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Republic of Singapore Lele Wu, Anandhkumar Raju, Thamil Selvan

Vaiyapuri, Khaireen Idzham, Joelle Yi Heng Chua, Bilal Unal & Vinay Tergaonkar * Beijing Neurosurgical Institute, Capital Medical University, Beijing, China Zheng Zhao, Yiyun Yin, You

Zhai, Wenhua Fan, Lijie Huang, Huimin Hu & Tao Jiang * Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea Yong Jae Shin, Miseol Son, Yeri Lee & 

Do-Hyun Nam * Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea Jason K. Sa * Beijing Tiantan Hospital, Capital Medical University, Beijing,

China Wenhua Fan & Tao Jiang * Laboratory of Translational Biomedical Proteomics, Institute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR),

Singapore, Republic of Singapore Jayantha Gunaratne * Department of Neurosurgery, Samsung Medical Center, Seoul, Republic of Korea Do-Hyun Nam * Department of Pathology, Yong Loo Lin School

of Medicine, National University of Singapore (NUS), Singapore, Republic of Singapore Vinay Tergaonkar * Department of Biochemistry, Yong Loo Lin School of Medicine, National University of

Singapore (NUS), Singapore, Republic of Singapore Vinay Tergaonkar Authors * Lele Wu View author publications You can also search for this author inPubMed Google Scholar * Zheng Zhao View

author publications You can also search for this author inPubMed Google Scholar * Yong Jae Shin View author publications You can also search for this author inPubMed Google Scholar * Yiyun

Yin View author publications You can also search for this author inPubMed Google Scholar * Anandhkumar Raju View author publications You can also search for this author inPubMed Google

Scholar * Thamil Selvan Vaiyapuri View author publications You can also search for this author inPubMed Google Scholar * Khaireen Idzham View author publications You can also search for this

author inPubMed Google Scholar * Miseol Son View author publications You can also search for this author inPubMed Google Scholar * Yeri Lee View author publications You can also search for

this author inPubMed Google Scholar * Jason K. Sa View author publications You can also search for this author inPubMed Google Scholar * Joelle Yi Heng Chua View author publications You can

also search for this author inPubMed Google Scholar * Bilal Unal View author publications You can also search for this author inPubMed Google Scholar * You Zhai View author publications You

can also search for this author inPubMed Google Scholar * Wenhua Fan View author publications You can also search for this author inPubMed Google Scholar * Lijie Huang View author

publications You can also search for this author inPubMed Google Scholar * Huimin Hu View author publications You can also search for this author inPubMed Google Scholar * Jayantha Gunaratne

View author publications You can also search for this author inPubMed Google Scholar * Do-Hyun Nam View author publications You can also search for this author inPubMed Google Scholar * Tao

Jiang View author publications You can also search for this author inPubMed Google Scholar * Vinay Tergaonkar View author publications You can also search for this author inPubMed Google

Scholar CORRESPONDING AUTHORS Correspondence to Tao Jiang or Vinay Tergaonkar. RIGHTS AND PERMISSIONS OPEN ACCESS This article is licensed under a Creative Commons Attribution 4.0

International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the

source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative

Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by

statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit

http://creativecommons.org/licenses/by/4.0/. ABOUT THIS ARTICLE CITE THIS ARTICLE Wu, L., Zhao, Z., Shin, Y.J. _et al._ Retraction Note: Tumour microenvironment programming by an

RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma. _Nat Cell Biol_ 27, 546 (2025). https://doi.org/10.1038/s41556-025-01613-0 Download citation

* Published: 16 January 2025 * Issue Date: March 2025 * DOI: https://doi.org/10.1038/s41556-025-01613-0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative