Hyperinflation and its association with successful transition to home ventilator devices in infants with chronic respiratory failure and severe bronchopulmonary dysplasia

ABSTRACT OBJECTIVE To estimate the association between lung hyperinflation and the time to successful transition to home ventilators in infants with sBPD and chronic respiratory failure.

DESIGN/METHODS Infants with sBPD <32 weeks’ gestation who received tracheostomies were identified. Hyperinflation was the main exposure. Time from tracheostomy to successful transition to

the home ventilator was the main outcome. Kaplan-Meier and multivariable Cox proportional hazards were used to estimate the relationships between hyperinflation and the main outcome.

RESULTS Sixty-two infants were included; 26 (42%) were hyperinflated. Eleven died before transition, and 51 successfully transitioned. Hyperinflation was associated with both mortality (31%

vs 8.3%, _p_ = 0.02) and an increased duration (72 vs. 56 days) to successful transition (hazard ratio (HR) = 0.38, 95% CI: 0.19, 0.76, _p_ = 0.006). Growth velocity was similar after

tracheostomy placement. CONCLUSIONS In infants with chronic respiratory failure and sBPD <32 weeks’ gestation, hyperinflation is related to mortality and inpatient morbidities. Access

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SIMILAR CONTENT BEING VIEWED BY OTHERS ESTABLISHED SEVERE BPD: IS THERE A WAY OUT? CHANGE OF VENTILATORY PARADIGMS Article 19 May 2021 FACTORS ASSOCIATED WITH LIBERATION FROM HOME MECHANICAL

VENTILATION AND TRACHEOSTOMY DECANNULATION IN INFANTS AND CHILDREN WITH SEVERE BRONCHOPULMONARY DYSPLASIA Article 31 July 2024 FIRST WEEK OF LIFE RESPIRATORY MANAGEMENT AND PULMONARY

VENTILATION/PERFUSION MATCHING IN INFANTS WITH BRONCHOPULMONARY DYSPLASIA: A RETROSPECTIVE OBSERVATIONAL STUDY Article Open access 02 December 2022 DATA AVAILABILITY All data generated or

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Central  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Feinberg School of Medicine, Northwestern University & The Ann and Robert H. Lurie Children’s

Hospital of Chicago, Chicago, IL, USA Megan Lagoski, Michael Reisfeld, Ryan J. Carpenter, Emilee Lamorena, Denise M. Goodman & Karna Murthy * The Children’s Hospitals Neonatal

Consortium, Dover, DE, USA Karna Murthy Authors * Megan Lagoski View author publications You can also search for this author inPubMed Google Scholar * Michael Reisfeld View author

publications You can also search for this author inPubMed Google Scholar * Ryan J. Carpenter View author publications You can also search for this author inPubMed Google Scholar * Emilee

Lamorena View author publications You can also search for this author inPubMed Google Scholar * Denise M. Goodman View author publications You can also search for this author inPubMed Google

Scholar * Karna Murthy View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS ML is the first and corresponding author of this paper and is

responsible for the initial study concept, writing and editing the original manuscript, and data abstracting. MR contributed to the article by data abstraction and contributing to the

methods and results section. RJC assisted in the RedCAP database design and edited the manuscript. EL assisted in research design and information regarding home ventilators. DG assisted in

the study design and in editing the manuscript. KM assisted in study design and analyzed the data. He also edited the manuscript. CORRESPONDING AUTHOR Correspondence to Megan Lagoski. ETHICS

DECLARATIONS COMPETING INTERESTS The authors have no relevant financial relationships or conflicts of interests to disclose related to the (1) study design; (2) collection, analysis, and

interpretation of data; (3) writing of the report; and (4) decision to submit the paper for publication. KM is a Board member of Children’s Hospitals Neonatal Consortium, a 501c3

organization that developed and maintained a database that was used to identify database records of infants for this project. This study was approved by the Ann and Robert H. Lurie

Children’s Hospital Institutional Review Board (IRB 2020-3773) and data obtained from Children’s Hospital Neonatal Database (IRB 2009-13982). ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer

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R.J. _et al._ Hyperinflation and its association with successful transition to home ventilator devices in infants with chronic respiratory failure and severe bronchopulmonary dysplasia. _J

Perinatol_ 43, 332–336 (2023). https://doi.org/10.1038/s41372-022-01575-3 Download citation * Received: 08 June 2022 * Revised: 25 October 2022 * Accepted: 29 November 2022 * Published: 13

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