Radiation-induced transgenerational instability

ABSTRACT To date, the analysis of mutation induction has provided an irrefutable evidence for an elevated germline mutation rate in the parents directly exposed to ionizing radiation and a

number of chemical mutagens. However, the results of numerous publications suggest that radiation may also have an indirect effect on genome stability, which is transmitted through the germ

line of irradiated parents to their offspring. This review describes the phenomenon of transgenerational instability and focuses on the data showing increased cancer incidence and elevated

mutation rates in the germ line and somatic tissues of the offspring of irradiated parents. The possible mechanisms of transgenerational instability are also discussed. Access through your

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many colleagues and collaborators for their important contribution to this work. This work was supported by grants from the Wellcome Trust. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

Department of Genetics, University of Leicester, Leicester, LE1 7RH, UK Yuri E Dubrova Authors * Yuri E Dubrova View author publications You can also search for this author inPubMed Google

Scholar CORRESPONDING AUTHOR Correspondence to Yuri E Dubrova. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Dubrova, Y. Radiation-induced

transgenerational instability. _Oncogene_ 22, 7087–7093 (2003). https://doi.org/10.1038/sj.onc.1206993 Download citation * Published: 13 October 2003 * Issue Date: 13 October 2003 * DOI:

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * instability * mutation * radiation * germline * mouse *

cancer