Effects of advanced glycosylation end-products (age) on autoregulation in afferent arterioles (aa) from diabetic rats. † 1647
Effects of advanced glycosylation end-products (age) on autoregulation in afferent arterioles (aa) from diabetic rats. † 1647"
- Select a language for the TTS:
- UK English Female
- UK English Male
- US English Female
- US English Male
- Australian Female
- Australian Male
- Language selected: (auto detect) - EN
Play all audios:
AGE have been shown to reduce systemic pressor responses to acetylcholine(ACh) and to quench nitric oxide (NO) in vitro. We studied the effects of AGE on autoregulation and the responses to
ACh and NO-synthase inhibition in juxtamedullary (JM) afferent arterioles (AA) from rats with 40-50 days diabetes mellitus (DM) induced via i.p. injection of 65 mg/kg streptozotocin. Blood
glucose was 447±20 mg/dl (n=10). JM AA were perfused in vitro with blood solutions containing fresh RBC's (Hct≈27%) suspended in either 6% bovine albumin or 6% AGE-albumin in Krebs
Ringer. The superfusate also contained AGE or albumin (1%). AGE were made by incubation of 6% albumin with 0.5 M glucose for 45 days at 37° C followed by dialysis. To control for the effects
of hyperglycemia, the glucose levels were 100 mg/dl in both solutions. Under these conditions, autoregulatory responses were evident: AA constricted 38±4% (n=8) in response to increased
(60-140 mmHg) perfusion pressure (PP). The same vessels showed substantial basal tone: 10μM ACh caused a 48±6% dilation and calcium channel blockade with 10 mM MnCl2 elicited a 109±11%
dilation at 100 mmHg. Significant basal NO production was evident, as 0.1 mM L-NAME constricted AA by 21±2% (n=9) at 100 mmHg PP. AGE dilated these AA (44±12% at 100 mmHg PP, n=8) at all PP
levels; addition of ACh resulted in a modest further dilation (15±9%) to diameters similar to those seen with ACh and normal perfusate. Hence, in the absence of hyperglycemia, the
vasodilatory action of AGE in DM AA is inconsistent with AGE reducing NO levels. Funded by Juvenile Diabetes Foundation International Grant #195079. AUTHOR INFORMATION AUTHORS AND
AFFILIATIONS * Pediatrics, SUNY, Stony Brook, New York, Physiology/Biophysics, SUNY, Stony Brook, New York Adam Ellinger, Jennifer Paccione, Leon C Moore & Frederick J Kaskel Authors *
Adam Ellinger View author publications You can also search for this author inPubMed Google Scholar * Jennifer Paccione View author publications You can also search for this author inPubMed
Google Scholar * Leon C Moore View author publications You can also search for this author inPubMed Google Scholar * Frederick J Kaskel View author publications You can also search for this
author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ellinger, A., Paccione, J., Moore, L. _et al._ EFFECTS OF ADVANCED
GLYCOSYLATION END-PRODUCTS (AGE) ON AUTOREGULATION IN AFFERENT ARTERIOLES (AA) FROM DIABETIC RATS. † 1647. _Pediatr Res_ 41 (Suppl 4), 277 (1997).
https://doi.org/10.1203/00006450-199704001-01666 Download citation * Issue Date: 01 April 1997 * DOI: https://doi.org/10.1203/00006450-199704001-01666 SHARE THIS ARTICLE Anyone you share the
following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer
Nature SharedIt content-sharing initiative
Trending News
Aarp vital voices: consumer fraud among u. S. Adults ages 45+: incidence, concern, protection, vulnerabilityThe Federal Trade Commission’s (FTC) 2020 Consumer Sentinel Report shows U.S. consumers filed more than 4.7 million repo...
How will the ukraine crisis play out in british politics? | thearticleToday had been billed as the day of reckoning in Ukraine. At the time of writing, reports of a Russian withdrawal have d...
Cristiano ronaldo – latest news information updated on may 29, 2025 | articles & updates on cristiano ronaldo | photos & videos | latestlyCristiano Ronaldo – Latest News Information updated on May 29, 2025 | Articles & Updates on Cristiano Ronaldo | Phot...
Four things you should never put in a textMemorial Day Sale! Join AARP for just $11 per year with a 5-year membership Join now and get a FREE gift. Expires 6/4 G...
Observation of an acoustic octupole topological insulatorABSTRACT Berry phase associated with energy bands in crystals can lead to quantised observables like quantised dipole po...
Latests News
Effects of advanced glycosylation end-products (age) on autoregulation in afferent arterioles (aa) from diabetic rats. † 1647AGE have been shown to reduce systemic pressor responses to acetylcholine(ACh) and to quench nitric oxide (NO) in vitro....
Bacteria cannot become resistantThe BDTA Dental Showcase was a huge success for Ultradex. The brand name change, the updated pack design and the new Ult...
Prep roundup : tustin reaches playoffs againThe Tustin girls’ basketball team qualified for the playoffs for the 21st consecutive season, clinching a spot with a 57...
Channelnews : is dji developing three new drones including mini 5 pro?DJI appears to be preparing three new drone models for release in the coming months, according to leaked images and FCC ...
The aarp minute: august 31, 2021Memorial Day Sale! Join AARP for just $11 per year with a 5-year membership Join now and get a FREE gift. Expires 6/4 G...