Early alterations of glucose metabolism in prepubertal obesity (ppob)

ABSTRACT The liver, muscles and adipose mass of adults with long-lasting obesity are insulin resistant. This explains why, despite chronic hyperinsulinism, they produce and utilize glucose

at a similar rate than normal adults. We studied (d2-glucose tracing, iv somatostatin, euglycemic clamp) 7 children (13 ± 0.5 yrs), obese (176 ± 9% ideal BW) for 5 ± 0.5 yrs, gaining 13.5 ±

1.4 kg kg/yr. Normoglycemic (82 ± 4 mg/dl) and hyperinsulinemic (22 ± 4 μU/ml) in the fasting state, they produce 2.5 times more glucose (295 ± 18 mg/min) than age-matched controls (C) and

than obese adults. The similar increase of glucose utilization suggests a large glucose uptake by the adipose tissue of pPOb. Normalized to BW, the glucose uptake of pPOb (3.6 ± 0.2

mg/kg.min) equalled that of C (3.7 ± 0.2). This indicates that the main component of BW in pPOb, adipose tissue, takes up a similar relative amount of glucose than the main component of BW

in C, lean body mass(as opposed to obese adults). Suppression of insulin by somatostatin reduced glucose utilization by 110 ± 19 mg/min in pPOb (C: 41 ± 14), as expected from an

insulin-sensitive enlarged adipose mass. But hyperinsulinic clamp increased glucose uptake in pPOb (250 ± 20 mg/ M2.min, insulin 402 uU/ml) much less than in C (366 ± 31, insulin 366 μU/ml),

as expected from insulin-resistant muscles. Glucose overproduction by the liver, overutilization by adipose tissue contrasting with muscle insulin resistance characterize recent obesity in

prepubertal children. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Service d'Endocrinologie, U 188 INSERM, Hôpital Saint Vincent de Paul, Paris P F Bougnères & E

Artavia Authors * P F Bougnères View author publications You can also search for this author inPubMed Google Scholar * E Artavia View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bougnères, P., Artavia, E. EARLY ALTERATIONS OF GLUCOSE METABOLISM IN PREPUBERTAL

OBESITY (pPOb). _Pediatr Res_ 23, 136 (1988). https://doi.org/10.1203/00006450-198801000-00212 Download citation * Issue Date: 01 January 1988 * DOI:

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