1658 regional and lobar pulmonary blood flow with high frequency ventilation

ABSTRACT We compared regional and lobar pulmonary blood flow in conventional mechanical ventilation (CV) and high frequency ventilation (HFV) to determine whether changes occur in the

distribution of lung perfusion. Fourteen supine anesthetized, paralyzed dogs were ventilated with room air using CV and HFV (tidal volume=2.5 ml/kg, frequency=10 Hz.) Blood gases, pulmonary

and systemic arterial pressures, and cardiac output were allowed to reach a steady state, at which time radioactive microspheres were injected. Arterial blood gases with CV showed PO2=94.3 ±

2.2 torr (mean ± S.E.), PCO2=34.5 ± 1.5 torr, and pH=7.35 ± .02. These values remained unchanged with HFV. Comparison of systemic and pulmonary arterial pressures, cardiac output and venous

admixture showed no significant differences. In 11 dogs, tissue samples from apical, nondependent, and dependent areas of the lungs were analyzed for changes in blood flow. Regional

pulmonary blood flow for apical, nondependent and dependent regions using CV were 44.82±7.06, 44. 89±5.04, and 94.45±6.49 ml/min/gm.dry wt, respectively. The corresponding flows using HFV

were 44.27±6.69, 46.47±4.47, and 93.83 ±6.38 ml/min/gm dry wt. These differences were not significant. In the remaining 3 animals, each lobe was analyzed for changes in total lobar blood

flow under conditions of CV and HFV, and total lobar blood flows were not different. We conclude that HFV does not produce significant changes in regional or lobar distribution or pulmonary

blood flow, or in overall hemodynamics. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Pediatrics and Anesthesiology/Critical Care Medicine, The Johns Hopkins

Medical Institutions, Baltimore, 21205, MD Frank R Gioia, Gregory Rinehart, Richard J Traystman & Mark C Rogers Authors * Frank R Gioia View author publications You can also search for

this author inPubMed Google Scholar * Gregory Rinehart View author publications You can also search for this author inPubMed Google Scholar * Richard J Traystman View author publications You

can also search for this author inPubMed Google Scholar * Mark C Rogers View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints

and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Gioia, F., Rinehart, G., Traystman, R. _et al._ 1658 REGIONAL AND LOBAR PULMONARY BLOOD FLOW WITH HIGH FREQUENCY VENTILATION. _Pediatr

Res_ 15 (Suppl 4), 719 (1981). https://doi.org/10.1203/00006450-198104001-01676 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-01676 SHARE

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