1639 neutrophil function in the immotile cilia syndrome (ics)

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1639 neutrophil function in the immotile cilia syndrome (ics)"


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ABSTRACT Patients with ICS have an increased frequency of sinusitis and respiratory infections. Abnormal ciliary movement likely contributes to these frequent infections. In addition,


abnormal neutrophil function has been reported previously for some patients with ICS. We have studied neutrophil function in ICS patients with the three known ultrastructural abnormalities


of cilia. Fifteen patients were examined. Their mean age was 12.1 years. Neutrophil functions included; migration assessed under agarose and in Boyden chambers, phagocytosis and killing of


Staphylococcus aureus 502A, and the metabolic activity of cells at rest and during phagocytosis as assessed by hexose monophosphate pathway activity, hydrogen peroxide production,


tetrazolium dye reduction and lysosomal degranulation. When tested, the patients were not on antibiotics. They were afebrile and free of acute infection. Normal neutrophils were studied in


parallel. Five patients with respiratory infections but normal cilia were also examined. No ICS patient demonstrated a significant abnormality in neutrophil migration. Phagocytosis and


killing of S. aureus was normal. There was no evidence of abnormal metabolism by cells at rest or during phagocytosis. Two patients with normal cilia had a transient decrease in neutrophil


migration during a respiratory infection. Our findings suggest that abnormal neutrophil function does not predispose, in a major way, to respiratory infection in patients with ICS. ARTICLE


PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Research Institute, Hospital for Sick Children and the University of Toronto, Canada Chris W Corkey, Joe O Minta, Peter Turner & Douglas


Biggar Authors * Chris W Corkey View author publications You can also search for this author inPubMed Google Scholar * Joe O Minta View author publications You can also search for this


author inPubMed Google Scholar * Peter Turner View author publications You can also search for this author inPubMed Google Scholar * Douglas Biggar View author publications You can also


search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Corkey, C., Minta, J., Turner, P. _et al._ 1639 NEUTROPHIL


FUNCTION IN THE IMMOTILE CILIA SYNDROME (ICS). _Pediatr Res_ 15 (Suppl 4), 716 (1981). https://doi.org/10.1203/00006450-198104001-01656 Download citation * Issue Date: 01 April 1981 * DOI:


https://doi.org/10.1203/00006450-198104001-01656 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is


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