AR-Vs not predictive in mCRPC | Nature Reviews Urology

Access through your institution Buy or subscribe A new report in _European Urology_ shows that expression of androgen receptor variants 7 and 9 (AR-V7 and AR-V9) measured in whole blood is

not predictive of treatment outcomes in patients with metastatic castration-resistant prostate cancer (mCRPC). “AR-Vs are truncated isoforms of the AR that retain constitutive activity and

are purported to be associated with resistance to novel hormonal therapies (abiraterone and enzalutamide),” explains Arun Azad, senior author of the study. “However, data from the ARMOR-3

trial called this belief into question; hence, we felt it was critical to assess AR-V7 and AR-V9 expression in patients with mCRPC to determine the predictive utility of these AR variants.”

This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our

best-value online-access subscription $29.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue

Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL

ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * To, S. Q. _ et al_. Expression of androgen receptor splice variant

7 or 9 in whole blood does not predict response to androgen-axis–targeting agents in metastatic castration-resistant prostate cancer. _Eur. Urol._

https://doi.org/10.1016/j.eururo.2018.01.007 (2018) Article  CAS  Google Scholar  * Attard, G. & Antonarakis, E. S. Prostate cancer: AR aberrations and resistance to abiraterone or

enzalutamide. _Nat. Rev. Urol._ 13, 697–698 (2016) Article  CAS  Google Scholar  Download references Authors * Clemens Thoma View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Thoma, C. AR-Vs not predictive in mCRPC. _Nat Rev Urol_ 15, 203 (2018).

https://doi.org/10.1038/nrurol.2018.24 Download citation * Published: 27 February 2018 * Issue Date: April 2018 * DOI: https://doi.org/10.1038/nrurol.2018.24 SHARE THIS ARTICLE Anyone you

share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the

Springer Nature SharedIt content-sharing initiative