Redirecting alternative splicing

Access through your institution Buy or subscribe Signal transducer and activator of transcription 3 (STAT3) exists in two main isoforms: STAT3α and STAT3β. STAT3β is generated by alternative

splicing, and its overexpression can induce apoptosis and inhibit tumour growth. This study used phosphorodiamidate morpholino oligomers to redirect STAT3 alternative splicing from STAT3α

to STAT3β. This splicing switch was associated with a reduced viability of cancer cells and tumour regression in a xenograft model, highlighting that redirection of alternative splicing

could be a novel approach for cancer therapy. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal

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ORIGINAL RESEARCH PAPER * Zammarchi, F. et al. Antitumorigenic potential of STAT3 alternative splicing modulation. _Proc. Natl Acad. Sci. USA_ 108, 17779–17784 (2011) Article  CAS  PubMed 

Google Scholar  Download references Authors * Charlotte Harrison View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Harrison, C. Redirecting alternative splicing. _Nat Rev Drug Discov_ 10, 902 (2011). https://doi.org/10.1038/nrd3619 Download citation *

Published: 01 December 2011 * Issue Date: December 2011 * DOI: https://doi.org/10.1038/nrd3619 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:

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