Fluorescein as a model molecular calculator with reset capability
Fluorescein as a model molecular calculator with reset capability"
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ABSTRACT The evolution of molecules capable of performing boolean operations1,2,3,4 has gone a long way since the inception of the first molecular AND5 logic gate, followed by other logic
functions, such as XOR6 and INHIBIT7, and has reached the stage where these tiny processors execute arithmetic calculations8,9,10,11,12,13,14,15. Molecular logic gates that process a variety
of chemical inputs can now be loaded with arrays of logic functions16, enabling even a single molecular species to execute distinct algebraic operations: addition and subtraction12.
However, unlike electronic or optical signals, the accumulation of chemical inputs prevents chemical arithmetic systems8,9,10,11,12 from resetting. Consequently, a set of solutions is
required to complete even the simplest arithmetic cycle. It has been suggested that these limitations can be overcome by washing off the input signals from solid supports8,9. An alternative
approach, which does not require solvent exchange or incorporation of bulk surfaces, is to reset the arithmetic system chemically. Ultimately, this is how some biological systems regenerate.
Here we report a highly efficient and exceptionally simple molecular arithmetic system based on a plain fluorescein dye, capable of performing a full scale of elementary addition and
subtraction algebraic operations. This system can be reset following each separate arithmetic step. The ability to selectively eradicate chemical inputs brings us closer to the realization
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our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS TRUMPET IS AN OPERATING SYSTEM FOR SIMPLE AND ROBUST CELL-FREE BIOCOMPUTING Article Open access 20 April 2023
DEVELOPMENT OF EPISTATIC YES AND AND PROTEIN LOGIC GATES AND THEIR ASSEMBLY INTO SIGNALLING CASCADES Article 27 July 2023 GENETIC CIRCUIT DESIGN AUTOMATION WITH CELLO 2.0 Article 23 February
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molecular switches. _Proc. Natl Acad. Sci._ 99, 4941–4944 (2002). Article Google Scholar Download references ACKNOWLEDGEMENTS Support from the European Union (HPRN-CT-2000-00029), the G.
M. J. Schmidt Minerva Center on Supramolecular Architecture and the Helen and Martin Kimmel Center for Molecular Design is greatly acknowledged. A. S. holds the Siegfried and Irma Ulmann
professorial chair. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, 76100, Israel David Margulies, Galina Melman
& Abraham Shanzer Authors * David Margulies View author publications You can also search for this author inPubMed Google Scholar * Galina Melman View author publications You can also
search for this author inPubMed Google Scholar * Abraham Shanzer View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to
Abraham Shanzer. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS
ARTICLE Margulies, D., Melman, G. & Shanzer, A. Fluorescein as a model molecular calculator with reset capability. _Nature Mater_ 4, 768–771 (2005). https://doi.org/10.1038/nmat1469
Download citation * Received: 22 March 2005 * Accepted: 25 July 2005 * Published: 11 September 2005 * Issue Date: 01 October 2005 * DOI: https://doi.org/10.1038/nmat1469 SHARE THIS ARTICLE
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