Predicting 68Ga-PSMA-PET–CT positivity for recurrent disease
Predicting 68Ga-PSMA-PET–CT positivity for recurrent disease"
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Using 68Ga-labelled prostate-specific membrane antigen (PSMA) ligand-positron-emission tomography (PET)–CT imaging can improve detection rates of recurrent prostate cancer. The largest study
to date, published in European Urology, shows that using this imaging modality to detect disease in patients with early biochemical recurrence after radical prostatectomy could influence
treatment decisions in these men. Two nomograms for predicting positive findings using this imaging modality have been developed to help select men who might benefit from undergoing this
procedure.
In total, 272 patients who had hormone-sensitive biochemical recurrence of prostate cancer, had received radical prostatectomy as their primary treatment, and had serum PSA values between
0.2 and 1.0 ng/ml at the time of imaging were included in the study. This cohort was split into two subgroups: very-low PSA values (0.2–0.5 ng/ml) and low PSA values (>0.5–1.0 ng/ml).
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