Wise contributes to renal allograft dysfunction

Access through your institution Buy or subscribe Wnt-modulator in surface ectoderm (WISE) promotes tubular atrophy and interstitial fibrosis, say researchers. Qian _ et al_. showed that WISE

mRNA was expressed in normal rat kidneys and in rat renal transplants. In a rat model of chronic allograft dysfunction, treatment with an anti-WISE neutralizing antibody improved graft

function, increased kidney β-catenin levels, attenuated glomerular and interstitial injury, and reduced proteinuria, renal injury biomarker levels, kidney infiltration of macrophages and T

cells, and the expression of immune response and profibrotic genes. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution

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Contact customer support ORIGINAL RESEARCH PAPER * Qian, X. _ et al_. Inhibition of WISE preserves renal allograft function. _J. Am. Soc. Nephrol._ doi:10.1681/ASN.2012010012 Article  Google

Scholar  Download references RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE WISE contributes to renal allograft dysfunction. _Nat Rev Nephrol_ 9, 64

(2013). https://doi.org/10.1038/nrneph.2012.267 Download citation * Published: 11 December 2012 * Issue Date: February 2013 * DOI: https://doi.org/10.1038/nrneph.2012.267 SHARE THIS ARTICLE

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