Pruning: a class I act | Nature Reviews Neuroscience

Access through your institution Buy or subscribe The authors used mice lacking the MHC class I molecules H2-Kb and H2-Db (_K__b__D__b−/−_ mice), the expression of which is known to be

regulated by retinal waves. Data from whole-cell recordings in LGN slices indicated that _K__b__D__b−/−_ LGN neurons received input from more RGC axons than did wild-type LGN neurons.

Moreover, the segregation of RGC axons into eye-specific LGN layers was impaired in _K__b__D__b−/−_ mice. Wild-type and _K__b__D__b−/−_ retinas showed similar retinal-wave activity,

suggesting that H2-Kb and/or H2-Db act downstream of neuronal activity to regulate synapse pruning and eye-specific segregation. > the effects of the absence of these molecules at 

retino-geniculate > synapses are not due to compromised immune function This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your

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our FAQs * Contact customer support REFERENCES * Lee, H. et al. Synapse elimination and learning rules co-regulated by MHC class I H2-Db. _Nature_ http://doi.org/10.1038/nature13154 (2014)

Article  CAS  PubMed  PubMed Central  Google Scholar  Download references Authors * Leonie Welberg View author publications You can also search for this author inPubMed Google Scholar

RELATED LINKS RELATED LINKS RELATED LINKS IN NATURE RESEARCH Blankenship, A. G. & Feller, M. B. Mechanisms underlying spontaneous patterned activity in developing neural circuits.

_Nature Rev. Neurosci._ 11, 18–29 (2010) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Welberg, L. Pruning: a class I act. _Nat Rev Neurosci_ 15,

280–281 (2014). https://doi.org/10.1038/nrn3732 Download citation * Published: 09 April 2014 * Issue Date: May 2014 * DOI: https://doi.org/10.1038/nrn3732 SHARE THIS ARTICLE Anyone you share

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