Pulling power of CAMK2α | Nature Reviews Neuroscience

Access through your institution Buy or subscribe CAMK2α and CAMK2β are expressed in neurons, and their kinase activity contributes to synaptic plasticity. Upon neuronal activation, both

isoforms move from the dendritic shaft to spines. The abundance of CAMK2 at synapses suggests that it may have an additional, structural role. Indeed, CAMK2β had been shown to mediate the

reorganization of the actin cytoskeleton, but a structural role for CAMK2α had not been demonstrated. In co-precipitation studies followed by mass spectrometry, the authors identified CAMK2α

as a brain proteasome-associated protein. After demonstrating that CAMK2α and proteasomes colocalize in cultured rat hippocampal neurons, they showed in time lapse imaging studies that

overexpression of CAMK2α enhanced NMDA (_N_-methyl-D-aspartate)-dependent recruitment of proteasomes to spines. By contrast, downregulation of CAMK2α expression by RNA interference or

expression of mutant forms of CAMK2α that are deficient in activity-dependent translocation impaired this proteasome accumulation, suggesting a crucial role for CAMK2α in proteasome

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PAPER * Bingol, B. et al. Autophosphorylated CaMKIIα acts as a scaffold to recruit proteasomes to dendritic spines. _Cell_ 140, 567–578 (2010) Article  CAS  PubMed  Google Scholar  FURTHER

READING * Tai, H.-C. & Schuman, E. M. Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction. _Nature Rev. Neurosci._ 9, 826–838 (2008) Article  CAS 

Google Scholar  Download references Authors * Claudia Wiedemann View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wiedemann, C. Pulling power of CAMK2α. _Nat Rev Neurosci_ 11, 223 (2010). https://doi.org/10.1038/nrn2829 Download citation * Issue Date:

April 2010 * DOI: https://doi.org/10.1038/nrn2829 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is

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