Repeat performance silences the crowd

Access through your institution Buy or subscribe We have known for some time that repetitive DNA and gene silencing are linked, and the idea that repeats might be involved in gene regulation

is an old one. However, direct evidence was lacking until now. The initial aim of Vera Schramke and Robin Allshire's study was to determine whether RNA interference (RNAi) — through

both post-transcriptional gene silencing (PTGS) and chromatin-based gene silencing (CBGS) — could silence non-centromeric genes in fission yeast in the same way that it had been shown to

silence centromeric repeats. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print

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local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL

RESEARCH PAPER * Schramke, V. & Allshire, R. Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing. _Science_ 301, 1069–1074 (2003) Article  CAS  Google

Scholar  FURTHER READING * Hannon, G. J. RNA interference. _Nature_ 418, 244–251 (2002) Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

Associate Editor, Nature Reviews Genetics, Nick Campbell Authors * Nick Campbell View author publications You can also search for this author inPubMed Google Scholar RELATED LINKS RELATED

LINKS WEB SITE Robin Allshire's laboratory RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Campbell, N. Repeat performance silences the crowd. _Nat

Rev Mol Cell Biol_ 4, 674 (2003). https://doi.org/10.1038/nrm1214 Download citation * Issue Date: 01 September 2003 * DOI: https://doi.org/10.1038/nrm1214 SHARE THIS ARTICLE Anyone you share

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