Stroke and myocardial infarction risk dependent on type of contraceptive pill

Access through your institution Buy or subscribe Other groups have assessed the effect of hormonal contraception on the risk of venous thromboembolism, but studies in which thrombotic stroke

and myocardial infarction were the measured outcomes are scarce and their results are inconsistent. Although rarer, adverse events associated with arterial complications can be more serious

than venous-associated events. Assessment of how oral contraceptive use influences a woman's risk of experiencing arterial-associated adverse events is therefore important to provide

full information to women on their contraceptive options. In this large-scale historical cohort study, records of 1,626,158 women aged 15–49 years from a public registry were used. Patient

records were excluded at the study outset if the individuals had prior gynaecologic, abdominal, breast, lung or haematologic cancer; venous or arterial thrombotic events; or cardiovascular

disease. Additionally, the researchers censored from the analysis all data obtained during pregnancy and 3 months postpartum, during switches between contraceptive types, for 3 years

following receipt of an intrauterine levonorgestrel-releasing device and while women underwent surgery or ovarian-stimulation therapy. Women who had undergone hysterectomy, bilateral

oophorectomy or sterilization were excluded, and those who underwent these procedures during the study had their records censored following the interventions. In total, the records used

amounted to 14,251,063 patient-years. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive

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RESEARCH PAPER * Lidegaard, Ø. _ et al_. Thrombotic stroke and myocardial infarction with hormonal contraception. _N. Engl. J. Med._ 366, 2257–2266 (2012) Article  CAS  PubMed Central 

Google Scholar  Download references Authors * Fiona Mitchell View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Mitchell, F. Stroke and myocardial infarction risk dependent on type of contraceptive pill. _Nat Rev Endocrinol_ 8, 443 (2012).

https://doi.org/10.1038/nrendo.2012.115 Download citation * Published: 26 June 2012 * Issue Date: August 2012 * DOI: https://doi.org/10.1038/nrendo.2012.115 SHARE THIS ARTICLE Anyone you

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