1635 EFFECTS OF INTENSIVE IN-HOSPITAL THERAPY ON LUNG FUNCTIONS AND EXERCISE TOLERANCE IN CYSTIC FIBROSIS (CF)
1635 EFFECTS OF INTENSIVE IN-HOSPITAL THERAPY ON LUNG FUNCTIONS AND EXERCISE TOLERANCE IN CYSTIC FIBROSIS (CF)"
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There is little information on the objective benefits of inhospital therapy in CF. We, therefore, studied the effects of a 13 day ± 2.6 SD (range 10-18 days) admission on lung functions and
exercise capacity in 15 CF patients with moderate to severe disease. Treatment consisted of intravenous antibiotics, postural drainage and exercise therapy. We measured resting vital
capacity (VC), residual volume (RV), total lung capacity (TLC), forced expired volume in 1 second (FEV1), specific airway conductance (SG), arterial oxygen saturation (SaO2), and exercise
adaptation and tolerance shortly after admission and before discharge. Adaptation to exercise was evaluated by the work capacity (Watts/kg), peak heart rate (PHR), exercise-induced changes
in SaO2 and the ratio of PHR to peak W/kg.
The results show that our 2-week treatment program brought about significant, objective improvements in lung function, exercise tolerance and exercise adaptation in CF patients.
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