Bet inhibitor attenuates heart failure

Access through your institution Buy or subscribe Patients with systolic HF are typically given antagonists of β-adrenergic receptors and of the renin–angiotensin axis, which decrease the

levels of stress-induced hormones and also reduce left ventricular (LV) remodelling. However, the 5-year mortality after an initial diagnosis of HF is 40%, so new treatments are needed.

Previous work from this group showed that BRD4 is a critical co-activator of pathologic gene transactivation during cardiomyocyte hypertrophy, and that the BRD4 inhibitor JQ1 could prevent

the development of cardiac hypertrophy and LV dysfunction if administered at the onset of pressure overload in mice. > Compared with placebo, JQ1 reduced signs of HF This is a preview of

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* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Duan, Q. et al. BET bromodomain inhibition suppresses innate inflammatory and

profibrotic transcriptional networks in heart failure. _Sci. Transl Med_. 9, eaah5084 (2017) Article  Google Scholar  Download references Authors * Megan Cully View author publications You

can also search for this author inPubMed Google Scholar RELATED LINKS RELATED LINKS RELATED LINKS IN NATURE RESEARCH Filippakopoulos, P. & Knapp, S. Targeting bromodomains: epigenetic

readers of lysine acetylation. _Nat. Rev. Drug Discov._ 13, 337–356 (2014) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Cully, M. BET inhibitor

attenuates heart failure. _Nat Rev Drug Discov_ 16, 453 (2017). https://doi.org/10.1038/nrd.2017.125 Download citation * Published: 29 June 2017 * Issue Date: July 2017 * DOI:

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