Angiotensin ii — a new tool in vasodilatory shock

Access through your institution Buy or subscribe Patients with vasodilatory shock, characterized by peripheral vasodilatation and low arterial blood pressure, who do not respond to

vasopressors (catecholamines or vasopressin) have a poor prognosis. In addition, current vasopressors have toxic effects at high doses. A new clinical trial now shows that in patients with

catecholamine-resistant vasodilatory shock, intravenous administration of angiotensin II increases blood-pressure levels and allows dose reductions of concomitant vasopressors. The

researchers randomly assigned patients with vasodilatory shock receiving high-dose vasopressors to angiotensin II (_n_ = 163) or placebo (_n_ = 158) infusions. At 3 h, 69.9% patients in the

angiotensin II group met the primary end point (mean arterial blood pressure ≥75 mmHg or an increase of ≥10 mmHg from baseline) compared with 23.4% in the placebo group. Patients receiving

angiotensin II had lower catecholamine requirements and cardiovascular SOFA scores than those receiving placebo. Rates of serious adverse events, as well as 28-day mortality, were similar in

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ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Khanna, A. _ et al_. Angiotensin II for the treatment

of vasodilatory shock. _N. Engl. J. Med._ http://dx.doi.org/10.1056/NEJMoa1704154 (2017) Download references Authors * Irene Fernández-Ruiz View author publications You can also search for

this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fernández-Ruiz, I. Angiotensin II — a new tool in vasodilatory shock.

_Nat Rev Cardiol_ 14, 384 (2017). https://doi.org/10.1038/nrcardio.2017.90 Download citation * Published: 14 June 2017 * Issue Date: July 2017 * DOI:

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