Influence of biperiden and bornaprine on sleep in healthy subjects

ABSTRACT Biperiden, 4 mg, an anticholinergic drug that is relatively selective for the M1 receptor subtype, and bornaprine, 4 mg, a nonselective M1 and M2 antagonist, were administered

orally in a randomized, double-blind design to twelve healthy volunteers to investigate the effect on polysomnographically recorded sleep. Both drugs suppressed rapid eye movement (REM)

sleep as reflected by an increase of REM latency and a decrease in the percentage of REM sleep period time with the effects of biperiden being more pronounced. No significant effect on slow

wave sleep was observed. The results of this study support the hypothesis that both the M1 and the M2 receptor subtype are involved in the regulation of REM sleep in humans. SIMILAR CONTENT

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15 April 2024 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * From the Psychiatric Department, University of Freiburg, Freiburg, D-Germany Fritz Hohagen M.D., Stephanie Lis M.A., 

Dieter Riemann Ph.D., Stephan Krieger M.A., C. Meyer M.D., Rosemarie Fritsch Montero M.D., Heinz Grunze M.D. & Mathias Berger M.D. Authors * Fritz Hohagen M.D. View author publications

You can also search for this author inPubMed Google Scholar * Stephanie Lis M.A. View author publications You can also search for this author inPubMed Google Scholar * Dieter Riemann Ph.D.

View author publications You can also search for this author inPubMed Google Scholar * Stephan Krieger M.A. View author publications You can also search for this author inPubMed Google

Scholar * C. Meyer M.D. View author publications You can also search for this author inPubMed Google Scholar * Rosemarie Fritsch Montero M.D. View author publications You can also search for

this author inPubMed Google Scholar * Heinz Grunze M.D. View author publications You can also search for this author inPubMed Google Scholar * Mathias Berger M.D. View author publications

You can also search for this author inPubMed Google Scholar ADDITIONAL INFORMATION Address reprint requests to: Dr. F. Hohagen, Psychiatric Department of the University of Freiburg,

Hauptstr. 5, W-79104 Freiburg, D-Germany. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hohagen, F., Lis, S., Riemann, D. _et al._ Influence of

Biperiden and Bornaprine on Sleep in Healthy Subjects. _Neuropsychopharmacol_ 11, 29–32 (1994). https://doi.org/10.1038/npp.1994.33 Download citation * Received: 02 November 1993 * Revised:

15 February 1994 * Accepted: 28 February 1994 * Issue Date: 01 August 1994 * DOI: https://doi.org/10.1038/npp.1994.33 SHARE THIS ARTICLE Anyone you share the following link with will be able

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initiative KEYWORDS * Bornaprine * Biperiden * Cholinergic system * REM sleep * Slow wave sleep