One nanoparticle, one kill | Nature Materials

By wrapping a ligand-functionalized lipid membrane around a silica core, nanoparticles with a fluid surface are created. These combine unprecedented specificity in binding to cancer cells

with the combinatorial delivery of drug cocktails. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS

Access through your institution Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Learn more Buy this article * Purchase on

SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about

institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Davis, M. E., Chen, Z. G. & Shin, D. M. _Nat. Rev. Drug Discov._ 7, 771–782 (2008). Article  CAS 

Google Scholar  * Farokhzad, O. C. & Langer, R. _ACS Nano_ 3, 16–20 (2009). CAS  Google Scholar  * Torchilin, V. P. _Nat. Rev. Drug Discov._ 4, 145–160 (2005). Article  CAS  Google

Scholar  * Ashley, C. E. et al. _Nature Mater_. 10, 389–397 (2011). Google Scholar  * Basha, S. et al. _Proc. Natl Acad. Sci. USA_ 103, 13509–13513 (2006). Article  CAS  Google Scholar  *

Ho, K., Lapitsky, Y., Shi, M. & Shoichet, M. S. _Soft Matter_ 5, 1074–1080 (2009). Article  CAS  Google Scholar  * Poon, Z. et al. _Angew. Chem. Int. Ed. Engl._ 49, 7266–7270 (2010).

Article  CAS  Google Scholar  * Taneichi, M. et al. _J. Immunol._ 177, 2324–2330 (2006). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

Darrell J. Irvine is in the Department of Biological Engineering, the Department of Materials Science and Engineering and the Koch Institute for Integrative Cancer Research, MIT, Cambridge,

Massachusetts 02139, USA, and the Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, Boston, Massachusetts 02129, USA. He is also an investigator of the Howard

Hughes Medical Institute, Maryland 20815, USA., Darrell J. Irvine Authors * Darrell J. Irvine View author publications You can also search for this author inPubMed Google Scholar

CORRESPONDING AUTHOR Correspondence to Darrell J. Irvine. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Irvine, D. One nanoparticle, one kill. _Nature

Mater_ 10, 342–343 (2011). https://doi.org/10.1038/nmat3014 Download citation * Published: 17 April 2011 * Issue Date: May 2011 * DOI: https://doi.org/10.1038/nmat3014 SHARE THIS ARTICLE

Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided

by the Springer Nature SharedIt content-sharing initiative