Research Highlights | Nature Immunology

Access through your institution Buy or subscribe NEW DIRECTIONS FOR IS Immune synapses form after cognate antigen recognition by T cells. In _Cell_, Dustin and colleagues show that such

immune synapses in naive T cells demonstrate dynamic activity and can transiently reorient through the opposing activities of protein kinase C-θ (PKC-θ) and WASP (the Wiscott-Aldrich

syndrome protein). Neither PKC-θ nor WASP is required for the formation of immune synapses, but PKC-θ, which is present as punctae in the peripheral supramolecular activation cluster,

directs the relocation of the immune synapse. T cells expressing PKC-θ form breaks in the symmetrical arrangement of their immune synapses and can translocate in the direction of the breaks.

In contrast, WASP is needed to reform the symmetrical immune synapse structure. _In vivo_ imaging shows that PKC-θ is required for dynamic sampling of dendritic cell networks by T cells.

These data indicate that immune synapses are much more dynamic structures than previously thought. _LAD_ This is a preview of subscription content, access via your institution ACCESS OPTIONS

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8, 685 (2007). https://doi.org/10.1038/ni0707-685 Download citation * Issue Date: July 2007 * DOI: https://doi.org/10.1038/ni0707-685 SHARE THIS ARTICLE Anyone you share the following link

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