Study finds no link between hyperinsulinemia and ad-related brain lesions

Access through your institution Buy or subscribe Alafuzoff I _ et al_. (2008) β-Amyloid depositon in brains of subjects with diabetes. _Neuropathol Appl Neurobiol_

[doi:10.1111/j.1365-2990.2008.00948.x] Whether the risk of Alzheimer's disease (AD) is increased in patients with diabetes mellitus is a matter of some debate. One hypothesis supporting

such a relationship is that, because insulin-degrading enzyme degrades not only insulin but also β-amyloid, the greater competition for this enzyme in patients with hyperinsulinemia might

result in higher β-amyloid loads. However, findings from a recent, retrospective postmortem study have challenged this claim. This is a preview of subscription content, access via your

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between hyperinsulinemia and AD-related brain lesions. _Nat Rev Neurol_ 4, 290 (2008). https://doi.org/10.1038/ncpneuro0795 Download citation * Issue Date: June 2008 * DOI:

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