Determinants of arterial wall stiffness and peripheral artery occlusive disease in nondiabetic hemodialysis patients

ABSTRACT Aortic pulse wave velocity (Ao-PWV) and ankle-brachial blood pressure index (ABPI) are significant prognostic factors in patients with end-stage renal disease (ESRD). Diabetes

mellitus (DM) promotes changes in arterial walls, including marked increases in Ao-PWV and decreases in ABPI. To determine the prevalence of peripheral arterial occlusive disease (PAOD) as

well as the clinical variables useful in predicting these changes in nondiabetic patients with ESRD undergoing hemodialysis (HD), we performed a cross-sectional study in a cohort of 143

patients. Ao-PWV and ABPI were measured simultaneously and compared with several annual biochemical measurements and other clinical variables. The prevalence of PAOD in our cohort was 30.5%.

In univariate regression analysis, Ao-PWV correlated positively with age, heart rate (HR), blood pressure (BP), pulse pressure (PP) and HbA1c, and negatively with serum albumin and ABPI.

ABPI correlated negatively with age, HD duration, systolic BP, PP, low-density lipoprotein (LDL) cholesterol and hypersensitive C-reactive protein (hs-CRP), and positively with serum albumin

and bone mineral density. In a step-down multiple regression analysis, HbA1c was identified as an independent determinant of Ao-PWV along with age, HD duration, HR and mean BP, while hs-CRP

was an independent contributor to ABPI along with age, HD duration, PP and LDL cholesterol. Our results suggest that HD promotes aortic wall stiffness and PAOD progression. We recommend the

monitoring of HbA1c to allow the prediction of aortic wall stiffness in nondiabetic ESRD patients. Our results did not confirm the influence of insulin resistance on the development of

arterial sclerosis lesions. SIMILAR CONTENT BEING VIEWED BY OTHERS INDIVIDUAL VERSUS INTEGRATION OF MULTIPLE COMPONENTS OF CENTRAL BLOOD PRESSURE AND AORTIC STIFFNESS IN PREDICTING

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15: 1014–1021. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Nephrology, Department of Internal Medicine, Kyorinkai Murakami

Memorial Hospital, Nakatsu, Japan Tomoji Matsumae, Genji Murakami, Motoichi Ishihara & Kazuo Ueda * Fourth Department of Internal Medicine, Fukuoka University School of Medicine,

Fukuoka, Japan Yasuhiro Abe & Takao Saito Authors * Tomoji Matsumae View author publications You can also search for this author inPubMed Google Scholar * Yasuhiro Abe View author

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Ishihara View author publications You can also search for this author inPubMed Google Scholar * Kazuo Ueda View author publications You can also search for this author inPubMed Google

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Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Matsumae, T., Abe, Y., Murakami, G. _et al._ Determinants of Arterial Wall Stiffness and Peripheral Artery Occlusive Disease in

Nondiabetic Hemodialysis Patients. _Hypertens Res_ 30, 377–385 (2007). https://doi.org/10.1291/hypres.30.377 Download citation * Received: 08 August 2006 * Accepted: 20 December 2006 * Issue

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shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * hemodialysis * arterial wall

stiffness * end-stage renal disease * ankle-brachial blood pressure index * aortic pulse wave velocity