Association of epstein–barr virus reactivation with the recovery of cd4/cd8 double-negative t lymphocytes after haploidentical hematopoietic stem cell transplantation

ABSTRACT EBV infection is one of the life-threatening clinical complications in patients who underwent haploidentical hematopoietic stem cell transplantation (haploHSCT). Although immune

recovery is recognized to be crucial for decreasing subsequent morbidity of infections, the link between T-cell recovery and EBV infection after haploHSCT remains elusive. We recently

compared the influences of different doses of antithymocyte globulin conditioning on the T-cell reconstitution post haploHSCT and suggested that CD4−CD8−T cells might interact with the

occurrence of EBV reactivation. In the current study, haploHSCT recipients with EBV-DNAemia (_n_=64) were compared with a control group without EBV reactivation (_n_=192), with regard to the

recoveries of T-cell subpopulations. In contrast to other T-cell subpopulations, the median counts ofCD4−CD8−T cells in recipients with EBV-DNAemia were significantly lower than the control

group at a serial time course (30, 90 and 180 days) after transplantation. Landmark studies further confirmed the correlation of CD4−CD8−T cells with the EBV infection. Multivariate

analysis showed that hampered recovery of CD4−CD8−T cells and EBV reactivation were the independent risk factors to predict transplant-related mortality. Our findings may facilitate the

intervention strategies to improve the overall survival of haploHSCT recipients. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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potential pinch hitters in the T-cell lineup. _Curr Opin HIV AIDS_ 2012; 7: 164–171. Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS This study is supported by Key Program

of the National Natural Science Foundation of China (Grant No 81230013) and National Natural Science Foundation of China (Grant No. 81370666). AUTHOR INFORMATION Author notes * Z Bian and J

Liu: These authors contributed equally to this work. AUTHORS AND AFFILIATIONS * Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key laboratory

of Hematopoietic Stem Cell Transplantation, Beijing, China Z Bian, J Liu, L-P Xu, Y-J Chang, Y Wang, X-H Zhang & X-J Huang Authors * Z Bian View author publications You can also search

for this author inPubMed Google Scholar * J Liu View author publications You can also search for this author inPubMed Google Scholar * L-P Xu View author publications You can also search for

this author inPubMed Google Scholar * Y-J Chang View author publications You can also search for this author inPubMed Google Scholar * Y Wang View author publications You can also search

for this author inPubMed Google Scholar * X-H Zhang View author publications You can also search for this author inPubMed Google Scholar * X-J Huang View author publications You can also

search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to X-J Huang. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. RIGHTS

AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bian, Z., Liu, J., Xu, LP. _et al._ Association of Epstein–Barr virus reactivation with the recovery of CD4/CD8

double-negative T lymphocytes after haploidentical hematopoietic stem cell transplantation. _Bone Marrow Transplant_ 52, 264–269 (2017). https://doi.org/10.1038/bmt.2016.238 Download

citation * Received: 18 April 2016 * Revised: 20 July 2016 * Accepted: 07 August 2016 * Published: 31 October 2016 * Issue Date: February 2017 * DOI: https://doi.org/10.1038/bmt.2016.238

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