Prognosis of conjunctival melanomas in relation to histopathological features

ABSTRACT Twenty-six patients (age 29-85 years) with primary malignant melanoma of the conjunctiva were analysed for usefulness of various histopathological and immunohistochemical features

of the primary, recurrent and metastatic tumours in evaluating their prognosis. The mean follow-up time was 5.5 years, ranging from 8 months to 17 years. Eight patients developed metastases

and seven have died. The mean time from diagnosis to death due to metastasis was 3.8 years (range 1-6 years). The site of the primary tumour seemed to be most closely correlated to high

metastatic risk. Only two of the sixteen limbal melanomas metastasised, whereas two of the four bulbar, all three tarsal and the only diffuse primary tumour caused metastatic disease. Two of

the metastasising primary tumours were less than 1.5 mm thick, but all exceeded 0.8 mm in thickness. The mitotic rate, the amount of inflammatory infiltrate, the cell type or the presence

of adjacent intraepithelial involvement did not obviously correlate to treatment outcome. Furthermore, the expression of S-100 protein and neuron-specific enolase (NSE), both suggested to be

prognostic indicators in cutaneous melanoma, did not correlate to the tendency of the conjunctival melanomas to recur or metastasise. Access through your institution Buy or subscribe This

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MELANOMA: OUTCOMES BASED ON TUMOUR ORIGIN IN 629 PATIENTS AT A SINGLE OCULAR ONCOLOGY CENTRE Article 26 March 2021 CLINICAL FEATURES AND SURVIVAL OUTCOMES OF OCULAR MELANOMA IN A

MULTI-ETHNIC ASIAN COHORT Article Open access 01 October 2020 RISK FACTORS AND PROGNOSIS OF ORBITAL EXENTERATION IN CONJUNCTIVAL MELANOMA Article 15 December 2022 AUTHOR INFORMATION AUTHORS

AND AFFILIATIONS * Department of Ophthalmology, Helsinki University Central Hospital, Finland U Fuchs Authors * U Fuchs View author publications You can also search for this author inPubMed 

Google Scholar * T Kivelä View author publications You can also search for this author inPubMed Google Scholar * K Liesto View author publications You can also search for this author

inPubMed Google Scholar * A Tarkkanen View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE

CITE THIS ARTICLE Fuchs, U., Kivelä, T., Liesto, K. _et al._ Prognosis of conjunctival melanomas in relation to histopathological features. _Br J Cancer_ 59, 261–267 (1989).

https://doi.org/10.1038/bjc.1989.55 Download citation * Issue Date: 01 February 1989 * DOI: https://doi.org/10.1038/bjc.1989.55 SHARE THIS ARTICLE Anyone you share the following link with

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