Phase ii study of lonidamine in metastatic breast cancer

ABSTRACT Thirty patients with previously treated metastatic breast cancer were entered in a phase II study with oral lonidamine. Twenty-eight patients are evaluable for toxicity and 25 for

response. A partial remission was obtained in four patients (16%) and disease stability in 11 (44%): 10 patients progressed (40%). Toxicity was acceptable, consisting mainly of myalgias (39%

of patients) and asthenia (21.4%). No myelotoxicity was observed. The drug is active in previously treated metastatic breast cancer and, because of its peculiar pattern of action and

toxicity, deserves to be evaluated in combination with cytotoxic chemotherapy. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS PHASE 2 STUDY OF CABAZITAXEL AS SECOND-LINE TREATMENT IN PATIENTS

WITH HER2-NEGATIVE METASTATIC BREAST CANCER PREVIOUSLY TREATED WITH TAXANES—A HELLENIC COOPERATIVE ONCOLOGY GROUP (HECOG) TRIAL Article Open access 03 June 2020 NEOADJUVANT STUDY OF

NIRAPARIB IN PATIENTS WITH HER2-NEGATIVE, _BRCA_-MUTATED, RESECTABLE BREAST CANCER Article Open access 04 July 2022 A PHASE 1B OPEN-LABEL STUDY OF GEDATOLISIB (PF-05212384) IN COMBINATION

WITH OTHER ANTI-TUMOUR AGENTS FOR PATIENTS WITH ADVANCED SOLID TUMOURS AND TRIPLE-NEGATIVE BREAST CANCER Article 05 November 2022 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Divisione di

Oncologia Medica, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy P Pronzato Authors * P Pronzato View author publications You can also search for this author inPubMed Google

Scholar * D Amoroso View author publications You can also search for this author inPubMed Google Scholar * G Bertelli View author publications You can also search for this author inPubMed 

Google Scholar * PF Conte View author publications You can also search for this author inPubMed Google Scholar * MP Cusimano View author publications You can also search for this author

inPubMed Google Scholar * GB Ciottoli View author publications You can also search for this author inPubMed Google Scholar * M Gulisano View author publications You can also search for this

author inPubMed Google Scholar * R Lionetto View author publications You can also search for this author inPubMed Google Scholar * R Rosso View author publications You can also search for

this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Pronzato, P., Amoroso, D., Bertelli, G. _et al._ Phase II study of

lonidamine in metastatic breast cancer. _Br J Cancer_ 59, 251–253 (1989). https://doi.org/10.1038/bjc.1989.51 Download citation * Issue Date: 01 February 1989 * DOI:

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