Calories lost — another mediator of cancer cachexia?

A novel proteoglycan induces cachexia in selected murine and human cancers. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Langstein, H.N. & Norton, J.A. Mechanisms of cancer cachexia. _Hematol. Oncol. Clin.

North Am._ 5, 103–123 (1991). Article  CAS  Google Scholar  * Balducci, L. & Hardy, C. Cancer and nutrition: A review. _Compr. Ther._ 13, 60 (1987). * Beutler, B. Cachexia: A fundamental

mechanism. _Nutr. Rev._ 46, 369 (1988). Article  CAS  Google Scholar  * Fearon, K.C.H. & Carter, D.C. Cancer cachexia. _Ann. Surg._ 208, 1 (1988). Article  CAS  Google Scholar  * Kern,

K.A. & Norton, J.A. Cancer cachexia. _JPEN J Parenter. Enteral Nutr._ 12, 286 (1988). Article  CAS  Google Scholar  * Norton, J.A., Peacock, J.L. & Morrison, S.D. Cancer cachexia.

_Crit. Rev. Oncol. Hematol._ 7, 289 (1987). Article  CAS  Google Scholar  * Grunfeld, C. & Feingold, K.R. Metabolic disturbances and wasting in the acquired immunodeficiency syndrome.

_N. Engl. J. Med._ 327, 329–337 (1992). Article  CAS  Google Scholar  * Cerami, A. Tumor necrosis factor as a mediator of shock, cachexia and inflammation. _Blood Purif._ 11, 108–117 (1993).

Article  CAS  Google Scholar  * Oliff, A. The role of tumor necrosis factor (cachectin) in cachexia. _Cell_ 54, 141 (1988). Article  CAS  Google Scholar  * Spiegelman, B.M. &

Hotamisligil, G.S. Through thick and thin: Wasting, obesity, and TNFα. _Cell_ 73, 625–627 (1993). Article  CAS  Google Scholar  * Beutler, B. & Cerami, A. Cachetin and tumour necrosis

factor as two sides of the same biological coin. _Nature_ 320, 584–588 (1986). Article  CAS  Google Scholar  * Strassmann, G., Fong, M., Kenney, J.S. & Jacob, C.O. Evidence for the

involvement of interleukin 6 in experimental cancer cachexia. _J. Clin. Invest._ 89, 1681–1684 (1992). Article  CAS  Google Scholar  * Grunfeld, C. _et al_. Endotoxin and cytokines induce

expression of leptin, the ob gene product, in hamsters: A role for leptin in the anorexia of infection. _J. Clin. Invest_, (in the press). * McDevitt, T.M., Todorov, P.T., Beck, S.A., Khan,

S.H. & Tisdale, M.J. Purification and characterization of a lipid-mobilizing factor associate with cachexin-inducing tumors in mice and humans. _Cancer Res._ 55, 1458–1463 (1995). CAS 

Google Scholar  * Todorov, P.T. _et al_. Characterization of a cancer cachectic factor. _Nature_ 379, 739–742 (1996). Article  CAS  Google Scholar  * Matthys, P. _et al_. Severe cachexia in

mice inoculated with interferon-gamma-producing tumor cells. _Int. J. Cancer_ 49, 77–82 (1991). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS

* Hughes Medical Institute, University of Michigan Medical Center, 1150 W. Medical Center Drive, Ann Arbor, Michigan, 48109-0650, USA Gary J. Nabel * Department of Veteran Affairs Medical

Center, University of California San Francisco, 4150 Clement Street (111F), San Francisco, California, 94114, USA Carl Grunfeld Authors * Gary J. Nabel View author publications You can also

search for this author inPubMed Google Scholar * Carl Grunfeld View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Nabel, G., Grunfeld, C. Calories lost — another mediator of cancer cachexia?. _Nat Med_ 2, 397–398 (1996). https://doi.org/10.1038/nm0496-397

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