Gentamicin pharmacokinetics in term newborn infants receiving high-frequency oscillatory ventilation or conventional mechanical ventilation: a case-controlled study
Gentamicin pharmacokinetics in term newborn infants receiving high-frequency oscillatory ventilation or conventional mechanical ventilation: a case-controlled study"
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ABSTRACT OBJECTIVE: To compare the pharmacokinetics of gentamicin in infants receiving high-frequency oscillatory ventilation (HFOV) with infants receiving conventional mechanical
ventilation. DESIGN: A case-controlled study design was used to compare the pharmacokinetics of gentamicin in critically ill infants receiving HFOV and conventional mechanical ventilation.
Medical records of all full-term newborn infants (≥37 weeks gestational age) who received either high-frequency mechanical ventilation or conventional mechanical ventilation between 1991 and
2001 were reviewed and relevant patient demographics, renal function tests and gentamicin administration and plasma concentration data collected. Elimination rate constant, half-life,
volume of distribution and clearance for both groups were calculated using standard kinetics equations. SETTING: A tertiary care children's hospital. PATIENTS: Newborn infants, ≥37
weeks gestational age, receiving gentamicin and high-frequency mechanical ventilation or conventional mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: In total, 18 patients were
included in the conventional mechanical ventilation group and 15 in the HFOV group. The mean gentamicin dose for conventional mechanical ventilation and HFOV groups infants were 2.52±0.07
and 2.5±0.07 mg/kg/dose, respectively. Initial dosing interval was 12 hours in all of the conventional mechanical ventilation infants and 13 of the 15 HFOV infants. The dosing interval for
the remaining two HFOV infants was 18 hours. No patient in either group demonstrated oliguria. Statistical analysis using the Student _t_-test for unequal variances yielded significant
differences between the two groups with regard to elimination rate constant, half-life, volume of distribution and clearance, with a _p_ value of <0.05 for all the observations. The mean
of the highest _P_aw received by each patient in the HFOV group (19.2±4.05) was considerably higher than in the conventional mechanical ventilation group (13.4+2.23) (_p_>0.05).
CONCLUSION: Infants receiving HFOV had reduced gentamicin clearance. Full-term infants receiving HFOV should be initiated at gentamicin dosing intervals of 18 hours rather than the
traditional 12 hours recommended for this age group. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS
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SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about
institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS HIGH-FREQUENCY OSCILLATORY VENTILATION WITH VOLUME GUARANTEE IN INFANTS: A
SYSTEMATIC REVIEW Article 20 March 2025 EVALUATION OF THREE NON-INVASIVE VENTILATION MODES AFTER EXTUBATION IN THE TREATMENT OF PRETERM INFANTS WITH SEVERE RESPIRATORY DISTRESS SYNDROME
Article 11 August 2022 ELECTIVE HIGH FREQUENCY OSCILLATORY VENTILATION VERSUS CONVENTIONAL MECHANICAL VENTILATION ON THE CHRONIC LUNG DISEASE OR DEATH IN PRETERM INFANTS ADMINISTERED
SURFACTANT: A SYSTEMATIC REVIEW AND META-ANALYSIS Article 02 December 2024 REFERENCES * Carlo WA, Martin RJ . Principals of neonatal assisted ventilation. _Pediatr Clin North Am_
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Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Clinical Sciences, College of Pharmacy, University of Michigan, MI, USA Varsha Bhatt-Mehta Pharm D,
FCCP * Department of Pediatrics and Communicable Diseases, University of Michigan, MI, USA Varsha Bhatt-Mehta Pharm D, FCCP & Steven M Donn MD Authors * Varsha Bhatt-Mehta Pharm D, FCCP
View author publications You can also search for this author inPubMed Google Scholar * Steven M Donn MD View author publications You can also search for this author inPubMed Google Scholar
ADDITIONAL INFORMATION Presented at the 31st Critical Care Congress, San Diego, CA, January 2002 and at the 18th Conference on High Frequency Ventilation, Snowbird, UT, April 2002. RIGHTS
AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bhatt-Mehta, V., Donn, S. Gentamicin Pharmacokinetics in Term Newborn Infants Receiving High-Frequency
Oscillatory Ventilation or Conventional Mechanical Ventilation: a Case-controlled Study. _J Perinatol_ 23, 559–562 (2003). https://doi.org/10.1038/sj.jp.7210985 Download citation *
Published: 20 October 2003 * Issue Date: 01 October 2003 * DOI: https://doi.org/10.1038/sj.jp.7210985 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this
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