Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils

ABSTRACT AN increase in vascular permeability as a result of the release of vasoactive amines has been implicated as a ‘trigger mechanism’ of immune complex deposition1,2. Several

immunological mechanisms of vasoactive amine release from rabbit platelets have been described3. Experiments have correlated the presence of one of these mechanisms, a

complement-independent, leukocyte-dependent reaction, with the vascular deposition of complexes in acute4 and chronic5 serum sickness of rabbits. We have obtained direct evidence that this

mechanism is due to basophils sensitised with IgE (ref. 6). Antigen-induced _in vitro_ degranulation of basophils from rabbits immunised with peroxidase yielded a soluble factor

(platelet-activating factor (PAF)) which aggregated rabbit platelets in leukocyte-free solutions6. Here we describe several characteristics of rabbit PAF and a PAF-like factor obtained from

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Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS EFFECTS OF BACTERIAL LIPOPOLYSACCHARIDES ON PLATELET FUNCTION: INHIBITION OF WEAK PLATELET ACTIVATION Article Open access 23

July 2020 PLATELET CXCL4 MEDIATES NEUTROPHIL EXTRACELLULAR TRAPS FORMATION IN ANCA-ASSOCIATED VASCULITIS Article Open access 08 January 2021 MOLECULAR ARCHITECTURE AND PLATELET-ACTIVATING

PROPERTIES OF SMALL IMMUNE COMPLEXES ASSEMBLED ON HEPARIN AND PLATELET FACTOR 4 Article Open access 11 March 2024 REFERENCES * Benacerraf, B., McCluskey, R. T., and Patras, D., _Am. J.

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references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * INSERM U 25, Clinique Néphrologique, Pr 5. Hamburger, Hôpital Necker, Paris, 75015, France J. BENVENISTE Authors * J. BENVENISTE View

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Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils. _Nature_ 249, 581–582 (1974). https://doi.org/10.1038/249581a0

Download citation * Received: 28 January 1974 * Issue Date: 07 June 1974 * DOI: https://doi.org/10.1038/249581a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to

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