Low oxygen enhancement ratios for radiosensitive bacterial strains, and the probable interaction of two types of primary lesion

ABSTRACT WHEN exposed to ionizing radiation, bacterial strains which are deficient in ability to by-pass or repair damage to nucleic acid have lower oxygen enhancement ratios (OERs) than

their more radioresistant parents1. This was predicted from a model in which the principal responsibility for the oxygen effect is attributed to a primary lesion of “type _O_”, whereas a

different primary lesion, “type _N_”, is more easily repaired or by-passed by some strains than others. With certain strains, notably _Escherichia coli B_, the lethal effects of type _N_

lesions are readily modified by post-irradiation culture conditions. The greater the extent of repair of type _N_ damage, the higher the OER2,3. Access through your institution Buy or

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INFORMATION AUTHORS AND AFFILIATIONS * MRC Experimental Radiopathology Research Unit, Hammersmith Hospital, Ducane Road, London TIKVAH ALPER Authors * TIKVAH ALPER View author publications

You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE ALPER, T. Low Oxygen Enhancement Ratios for

Radiosensitive Bacterial Strains, and the Probable Interaction of Two Types of Primary Lesion. _Nature_ 217, 862–863 (1968). https://doi.org/10.1038/217862a0 Download citation * Received: 30

November 1967 * Revised: 22 January 1968 * Issue Date: 02 March 1968 * DOI: https://doi.org/10.1038/217862a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read

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