Quality of life associated with acute and chronic graft-versus-host disease

ABSTRACT Acute and chronic graft-versus-host diseases (GVHD) are associated with increased morbidity and mortality after hematopoietic stem cell transplantation (HCT). We prospectively

measured the quality of life (QOL) of patients undergoing allogeneic transplantation. Ninety-six subjects completed self-assessment surveys before HCT, and at 6 and/or 12 months post-HCT

that included the Medical Outcomes Study Short Form 12 (SF12) and the Functional Assessment of Cancer Therapy-Bone Marrow Transplant scale. Eighty-three percent of survivors responded at 6

and 12 months. Physical and mental functioning assessed by the SF12 was not associated with either acute or chronic GVHD. In contrast, the trial outcome index (TOI) of the Functional

Assessment of Cancer Therapy-Bone Marrow Transplant was sensitive to occurrence of either acute or chronic GVHD. GVHD is a major determinant of the long-term QOL of survivors. The adverse

effects of acute GVHD are detectable with the TOI at 6 months post transplantation after which development of chronic GVHD is the most strongly correlated with worse QOL. Access through your

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Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS We thank the patients who participated in this study. This work was funded in part by P01 HL070149 from the National Heart,

Lung and Blood Institute and the Amy Strelzer-Manasevit Scholars Award. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Medical Oncology, Dana-Farber Cancer Institute, Boston,

MA, USA S J Lee, V T Ho, C Cutler, E P Alyea, R J Soiffer & J H Antin * Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA H T Kim

Authors * S J Lee View author publications You can also search for this author inPubMed Google Scholar * H T Kim View author publications You can also search for this author inPubMed Google

Scholar * V T Ho View author publications You can also search for this author inPubMed Google Scholar * C Cutler View author publications You can also search for this author inPubMed Google

Scholar * E P Alyea View author publications You can also search for this author inPubMed Google Scholar * R J Soiffer View author publications You can also search for this author inPubMed 

Google Scholar * J H Antin View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to S J Lee. RIGHTS AND PERMISSIONS

Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Lee, S., Kim, H., Ho, V. _et al._ Quality of life associated with acute and chronic graft-versus-host disease. _Bone Marrow

Transplant_ 38, 305–310 (2006). https://doi.org/10.1038/sj.bmt.1705434 Download citation * Received: 15 February 2006 * Revised: 30 May 2006 * Accepted: 02 June 2006 * Published: 03 July

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acute graft-versus-host disease * chronic graft-versus-host disease * stem cell transplantation