1190 effect of human growth hormone (hgh) treatment on fat metabolism

ABSTRACT Administration of pharmacological quantities of hGH to humans and animals causes a brisk rise in serum free fatty acids (FFA). Studies in fasting GH-deficient humans have yielded

divergent results. Adults show unimpaired lipolysis or even increased lipolysis and ketogenesis; hypopituitary children had normal beta-hydroxybutyrate (BOHB) levels which decreased with hGH

treatment. To resolve this issue we measured fat-derived fuels in 14 GH-deficient children (11.3±5.3 years, mean±S.D.) fasted for 24 hours, before and after three months of treatment with

conventional doses of hGH, and 18 normal fasting children (9.1±4.5 yrs). In all three groups BOHB levels correlated inversely with age and with glucose concentrations. On fasting, FFA

(p<0.025) and BOHB (p<0.025) were lower in GH-deficient than in normal children. Although hGH treatment caused only a small increase in FFA (p<0.25), BOHB increased significantly

(p<0.05). Although lipolysis and ketogenesis increase in fasting GH-deficient children, growth hormone is required for these processes to occur optimally. ARTICLE PDF AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * Tufts University School of Medicine, New England Medical Center, Boston Joseph I Wolfsdorf, Abdollah Sadeghi-Nejad & Boris Senior Authors * Joseph I Wolfsdorf

View author publications You can also search for this author inPubMed Google Scholar * Abdollah Sadeghi-Nejad View author publications You can also search for this author inPubMed Google

Scholar * Boris Senior View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Wolfsdorf, J., Sadeghi-Nejad, A. & Senior, B. 1190 EFFECT OF HUMAN GROWTH HORMONE (hGH) TREATMENT ON FAT METABOLISM. _Pediatr Res_ 15 (Suppl 4), 641 (1981).

https://doi.org/10.1203/00006450-198104001-01216 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-01216 SHARE THIS ARTICLE Anyone you share the

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