Allogeneic stem cell transplantation after reduced-intensity conditioning in a patient with t-cell prolymphocytic leukemia: graft-versus-tumor effect and long-term remission

Access through your institution Buy or subscribe T-cell prolymphocytic leukemia (T-PLL) is a rare aggressive lymphoid malignancy associated with a short median patient survival and poor

response to chemotherapy.1, 2, 3 Currently, there is no standard treatment for T-PLL, and disease progression ultimately occurs in most cases. Allogeneic stem cell transplantation (allo-SCT)

with myeloablative conditioning has been used in a few cases with T-PLL.2, 4, 5, 6 However, treatment-related mortality is significant with this kind of conditioning, precluding its use in

elderly or heavily pre-treated patients. However, reduced-intensity conditioning (RIC) allo-SCT has been shown to be associated with decreased transplant-related toxicities while preserving

the graft-versus-tumor effect (GVT).7 We report the case of a T-PLL patient successfully treated with RIC allo-SCT. In January 2002, a 30-year-old male with a previous history of type 1

diabetes, presented with fever, poor general condition and abdominal pain. Physical examination revealed liver enlargement, without peripheral adenopathy. The white blood-cell count was 57 ×

109/l with 73% abnormal lymphocytes. Platelets were low at 48 × 109/l. Bone marrow aspirate showed 52% abnormal T-lymphocytes compatible with a diagnosis of T-PLL. Flow cytometric analysis

of bone marrow lymphocytes revealed a characteristic post-thymic T-cell phenotype (CD2+, CD5+, CD7+, CD8+, HLA DR+, CD25−). CT-scan showed homogenous liver enlargement and signs of lung

infection. Cytogenetic analysis of the abnormal T lymphocytes was normal. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your

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our FAQs * Contact customer support REFERENCES * Matutes E, Brito-Babapulle V, Swansbury J, Ellis J, Morilla R, Dearden C _et al_. Clinical and laboratory features of 78 cases of

T-prolymphocytic leukemia. _Blood_ 1991; 78: 3269–3274. CAS  PubMed  Google Scholar  * Dearden CE, Matutes E, Cazin B, Tjonnfjord GE, Parreira A, Nomdedeu B _et al_. High remission rate in

T-cell prolymphocytic leukemia with CAMPATH-1 H. _Blood_ 2001; 98: 1721–1726. Article  CAS  Google Scholar  * Keating MJ, Cazin B, Coutre S, Birhiray R, Kovacsovics T, Langer W _et al_.

Campath-1 H treatment of T-cell prolymphocytic leukemia in patients for whom at least one prior chemotherapy regimen has failed. _J Clin Oncol_ 2002; 20: 205–213. Article  CAS  Google

Scholar  * Collins RH, Pineiro LA, Agura ED, Fay JW . Treatment of T prolymphocytic leukemia with allogeneic bone marrow transplantation. _Bone Marrow Transplant_ 1998; 21: 627–628. Article

  CAS  Google Scholar  * Tanimoto TE, Hirano A, Nagafuji K, Yamasaki S, Hashiguchi M, Okamura T _et al_. Mismatched unrelated cord blood transplantation in a patient with T-cell

prolymphocytic leukemia. _Leukemia_ 2005; 19: 679–681. Article  CAS  Google Scholar  * Murase K, Matsunaga T, Sato T, Kuribayashi K, Kogawa K, Kawano Y _et al_. Allogeneic bone marrow

transplantation in a patient with T-prolymphocytic leukemia with small-intestinal involvement. _Int J Clin Oncol_ 2003; 8: 391–394. Article  Google Scholar  * Mohty M, Bay JO, Faucher C,

Choufi B, Bilger K, Tournilhac O _et al_. Graft-versus-host disease following allogeneic transplantation from HLA-identical sibling with antithymocyte globulin-based reduced-intensity

preparative regimen. _Blood_ 2003; 102: 470–476. Article  CAS  Google Scholar  * Garderet L, Bittencourt H, Kaliski A, Daniel M, Ribaud P, Socie G _et al_. Treatment of T-prolymphocytic

leukemia with nonmyeloablative allogeneic stem cell transplantation. _Eur J Haematol_ 2001; 66: 137–139. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * Unité de Transplantation et de Thérapie Cellulaire, Institut Paoli-Calmettes, Marseille, France H de Lavallade, C Faucher, S Fürst, J El-Cheikh, D Blaise & M Mohty *

Département d'Hématologie, Institut Paoli-Calmettes, Marseille, France N Vey, D Coso, R Bouabdallah, A-M Stoppa & J-A Gastaut * Université de la Méditerranée, Marseille, France J-A

Gastaut, D Blaise & M Mohty Authors * H de Lavallade View author publications You can also search for this author inPubMed Google Scholar * C Faucher View author publications You can

also search for this author inPubMed Google Scholar * S Fürst View author publications You can also search for this author inPubMed Google Scholar * J El-Cheikh View author publications You

can also search for this author inPubMed Google Scholar * N Vey View author publications You can also search for this author inPubMed Google Scholar * D Coso View author publications You can

also search for this author inPubMed Google Scholar * R Bouabdallah View author publications You can also search for this author inPubMed Google Scholar * A-M Stoppa View author

publications You can also search for this author inPubMed Google Scholar * J-A Gastaut View author publications You can also search for this author inPubMed Google Scholar * D Blaise View

author publications You can also search for this author inPubMed Google Scholar * M Mohty View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE de Lavallade, H., Faucher, C., Fürst, S. _et al._ Allogeneic stem cell transplantation after reduced-intensity

conditioning in a patient with T-cell prolymphocytic leukemia: graft-versus-tumor effect and long-term remission. _Bone Marrow Transplant_ 37, 709–710 (2006).

https://doi.org/10.1038/sj.bmt.1705294 Download citation * Published: 13 February 2006 * Issue Date: 01 April 2006 * DOI: https://doi.org/10.1038/sj.bmt.1705294 SHARE THIS ARTICLE Anyone you

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