Reversal of penicillin inhibition by a yeast extract

ABSTRACT THE preparation from yeast of a growth-factor for _Corynebacterium diphtheri_1,2 has shown the active concentrates to be complex mixtures containing amino-acids and peptides, one of

the latter yielding on hydrolysis serine, glycine and glutamic acid. Attempted removal of the reducing substances present by osazone formation led to destruction of the activity, and some

component of the mixture gave a positive reaction in the Elson and Morgan3 test for amino-sugars ; the colour produced was not, however, identical with that obtained with glucosamine, and

the conditions required suggested the presence of an acylated amino-aldehyde. With a mixture of such complexity there was nothing to indicate that these observations were interconnected ;

but certain speculative considerations based on the above led to the search for a relationship between the active extract and the inhibitory effect of penicillin on Gram-positive

micro-organisms. This search was encouraged by the similarity between certain of the components of the yeast preparation and the fragments obtained on partial hydrolysis of penicillin.

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support SIMILAR CONTENT BEING VIEWED BY OTHERS NEW POTENTIATORS OF AMPHOTERICIN B ACTIVITY, SHODOAMIDES A TO C PRODUCED BY _PSEUDOPHIALOPHORA_ SP. BF-0158 Article 21 July 2023 CHEMICAL

COMPOSITION OF ANTI-MICROBIALLY ACTIVE FRACTIONS DERIVED FROM EXTRACT OF FILAMENTOUS FUNGUS _KERATINOPHYTON LEMMENSII_ INCLUDING THREE NOVEL BIOACTIVE COMPOUNDS Article Open access 25

October 2024 A NEW CLASS OF ANTIMICROBIAL MOLECULES DERIVED FROM KEFIR, EFFECTIVE AGAINST _PSEUDOMONAS AERUGINOSA_ AND METHICILLIN RESISTANT _STAPHYLOCOCCUS AUREUS_ (MRSA) STRAINS Article

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Medicine, University of Leeds, F. W. CHATTAWAY, D. A. HALL, F. C. HAPPOLD & E. S. HOLDSWORTH Authors * F. W. CHATTAWAY View author publications You can also search for this author

inPubMed Google Scholar * D. A. HALL View author publications You can also search for this author inPubMed Google Scholar * F. C. HAPPOLD View author publications You can also search for

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ABOUT THIS ARTICLE CITE THIS ARTICLE CHATTAWAY, F., HALL, D., HAPPOLD, F. _et al._ Reversal of Penicillin Inhibition by a Yeast Extract. _Nature_ 164, 314–315 (1949).

https://doi.org/10.1038/164314a0 Download citation * Issue Date: 20 August 1949 * DOI: https://doi.org/10.1038/164314a0 SHARE THIS ARTICLE Anyone you share the following link with will be

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