Reversal of penicillin inhibition by a yeast extract

Nature

Reversal of penicillin inhibition by a yeast extract"


Play all audios:

Loading...

ABSTRACT THE preparation from yeast of a growth-factor for _Corynebacterium diphtheri_1,2 has shown the active concentrates to be complex mixtures containing amino-acids and peptides, one of


the latter yielding on hydrolysis serine, glycine and glutamic acid. Attempted removal of the reducing substances present by osazone formation led to destruction of the activity, and some


component of the mixture gave a positive reaction in the Elson and Morgan3 test for amino-sugars ; the colour produced was not, however, identical with that obtained with glucosamine, and


the conditions required suggested the presence of an acylated amino-aldehyde. With a mixture of such complexity there was nothing to indicate that these observations were interconnected ;


but certain speculative considerations based on the above led to the search for a relationship between the active extract and the inhibitory effect of penicillin on Gram-positive


micro-organisms. This search was encouraged by the similarity between certain of the components of the yeast preparation and the fragments obtained on partial hydrolysis of penicillin.


Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this


journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now


Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer


support SIMILAR CONTENT BEING VIEWED BY OTHERS NEW POTENTIATORS OF AMPHOTERICIN B ACTIVITY, SHODOAMIDES A TO C PRODUCED BY _PSEUDOPHIALOPHORA_ SP. BF-0158 Article 21 July 2023 CHEMICAL


COMPOSITION OF ANTI-MICROBIALLY ACTIVE FRACTIONS DERIVED FROM EXTRACT OF FILAMENTOUS FUNGUS _KERATINOPHYTON LEMMENSII_ INCLUDING THREE NOVEL BIOACTIVE COMPOUNDS Article Open access 25


October 2024 A NEW CLASS OF ANTIMICROBIAL MOLECULES DERIVED FROM KEFIR, EFFECTIVE AGAINST _PSEUDOMONAS AERUGINOSA_ AND METHICILLIN RESISTANT _STAPHYLOCOCCUS AUREUS_ (MRSA) STRAINS Article


Open access 15 October 2020 REFERENCES * Chattaway, F. W., Dolby, D. E., Hall, D. A., and Happold, F. C., _Biochem. J._, 43, lix (1948). Article  CAS  Google Scholar  * Chattaway, F. W.,


Dolby, D. E., Hall, D. A., and Happold, F. C., _Biochem. J._ (in the press). * Elson, L. A., and Morgan, W. T. J., _Biochem. J._, 27, 1824 (1933). Article  CAS  Google Scholar  * Chattaway,


F. W., Happold, F. C., and Sandford, M., _Biochem. J._, 38, 111 (1944). Article  CAS  Google Scholar  * Gale, E. F., and Rodwell, A. W., _J. Gen. Microbiol._, 3, 127 (1944). Article  Google


Scholar  * Somogyi, M., _J. Biol. Chem._, 160, 61 (1945). CAS  Google Scholar  * de Haun, P. G., and Winkler, K. C., _Arch. Biochem._, 18, 97 (1948). Google Scholar  * Park, J. T., and


Johnson, M. J., _J. Biol. Chem._, 179, 585 (1949). CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Biochemistry, School of


Medicine, University of Leeds, F. W. CHATTAWAY, D. A. HALL, F. C. HAPPOLD & E. S. HOLDSWORTH Authors * F. W. CHATTAWAY View author publications You can also search for this author


inPubMed Google Scholar * D. A. HALL View author publications You can also search for this author inPubMed Google Scholar * F. C. HAPPOLD View author publications You can also search for


this author inPubMed Google Scholar * E. S. HOLDSWORTH View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions


ABOUT THIS ARTICLE CITE THIS ARTICLE CHATTAWAY, F., HALL, D., HAPPOLD, F. _et al._ Reversal of Penicillin Inhibition by a Yeast Extract. _Nature_ 164, 314–315 (1949).


https://doi.org/10.1038/164314a0 Download citation * Issue Date: 20 August 1949 * DOI: https://doi.org/10.1038/164314a0 SHARE THIS ARTICLE Anyone you share the following link with will be


able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing


initiative


Trending News

Prince philip forced to step down from dream role because of the queen

Prince Philip and the Queen's marriage has been praised as the embodiment of unity and duty throughout the pair...

Page Not Found

Page Not Found The content that you're looking for is unavailable. You might find what you are looking for by using the ...

Sc labor participation still falling - fitsnews

PALMETTO WORKFORCE SHRINKS AGAIN … The percentage of working age South Carolinians who are part of the labor force dippe...

Total amount lionel messi and kylian mbappe can pocket from world cup

The World Cup will draw to a close on Sunday, with two different storylines waiting to unfold. A victory for Argentina w...

Ww3 fears: indian army blocks chinese troops in fresh border clashes

Military chiefs in New Delhi said Indian troops were mobilised after spotting the Chinese troops' movement. China r...

Latests News

Reversal of penicillin inhibition by a yeast extract

ABSTRACT THE preparation from yeast of a growth-factor for _Corynebacterium diphtheri_1,2 has shown the active concentra...

Whatsapp on apple watch: can you get whatsapp on apple watch 4?

WhatsApp is now available on all smartphone platforms from Android to Apple. And a spike in smartwatch sales means custo...

Sa20 auction 2022: complete list of sold and unsold players at sa20 players auction

The player auction for the inaugural season of South Africa’s upcoming new T20 League, the SA20 was held in Capetown on ...

Repeated temperature modulation epitaxy for p-type doping and light-emitting diode based on zno

ABSTRACT Since the successful demonstration of a blue light-emitting diode (LED)1, potential materials for making short-...

How to get to sleep in cold weather - dr pixie's tips

As the temperature plummets during the winter, it can be hard for some people to fall asleep at night. “Many of us would...

Top