Genomic instability and bystander effects: a historical perspective

ABSTRACT Data have been emerging over the past two decades concerning two phenomena in which important biological effects of ionizing radiation arise in cells that in themselves receive no

radiation exposure. In the first, radiation-induced genomic instability, biological effects occur in the progeny of the irradiated cell after many generations of cell division. In the

second, radiation-induced bystander effects, they arise in cells that receive no radiation exposure as a consequence of damage signals transmitted from neighboring irradiated cells;

transmission may be mediated either by direct intercellular communication through gap junctions, or by factors released into the surrounding medium. In both phenomena, the biological effects

appear to be associated with an upregulation of oxidative metabolism. The present paper is designed to review the historical background leading to our current knowledge of these two

phenomena, and to indicate some future directions for research that will allow us to assess better their importance in the health effects of exposure to ionizing radiation. Access through

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BEING VIEWED BY OTHERS DATASETS OF _IN VITRO_ CLONOGENIC ASSAYS SHOWING LOW DOSE HYPER-RADIOSENSITIVITY AND INDUCED RADIORESISTANCE Article Open access 08 September 2022 RMI1 FACILITATES

REPAIR OF IONIZING RADIATION–INDUCED DNA DAMAGE AND MAINTENANCE OF GENOMIC STABILITY Article Open access 25 November 2023 INVESTIGATING THE IMPACT OF LONG TERM EXPOSURE TO CHEMICAL AGENTS ON

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Grant FG02-98ER62685 from the United States Department of Energy. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Laboratory of Radiobiology, Harvard School of Public Health, 665 Huntington

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_Oncogene_ 22, 6978–6987 (2003). https://doi.org/10.1038/sj.onc.1206988 Download citation * Published: 13 October 2003 * Issue Date: 13 October 2003 * DOI:

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * genomic instability * bystander effect * ionizing

radiation * clastogenic factors * oxidative stress * gap junction intercellular communication