Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells
Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells"
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ABSTRACT Cancer development is a multistage process that results from the step-wise acquisition of somatic alterations in diverse genes. Recent studies indicate that caveolin-1 expression
correlates with the level of oncogenic transformation in NIH3T3 cells, suggesting that caveolin in caveolae may regulate normal cell proliferation. In order to better understand potential
functions of caveolin-1 in cancer development, we have studied expression levels of caveolin-1 in human breast cancer cells, and have found that caveolin expression is significantly reduced
in human breast cancer cells compared with their normal mammary epithelial counterparts. When the caveolin cDNA linked to the CMV promoter is transfected into human mammary cancer cells
having no detectable endogenous caveolin, overexpression of caveolin-1 resulted in substantial growth inhibition, as seen by the 50% decrease in growth rate and by ∼l5-fold reduction in
colony formation in soft agar. In addition, characterization of caveolin-1 expression during cell cycle progression indicates that expression of α-caveolin-1 is regulated during cell cycle.
Furthermore p53-deficient cells showed a loss in caveolin expression. In summary, the overall expression patterns, its ability to inhibit tumor growth in culture, its regulation during the
cell cycle, and the loss of expression in p53-deficient cells all are consistent with an important growth regulating function for caveolin-1 in normal human mammary cells, that needs to be
repressed in oncogenic transformation and tumor cell growth. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS
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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS CAVEOLIN-1 KNOCKOUT MITIGATES BREAST CANCER METASTASIS TO THE LUNGS VIA INTEGRIN
Α3 DYSREGULATION IN 4T1-INDUCED SYNGENEIC BREAST CANCER MODEL Article Open access 07 September 2024 CAVEOLIN-1 GENE EXPRESSION PROVIDES ADDITIONAL PROGNOSTIC INFORMATION COMBINED WITH PAM50
RISK OF RECURRENCE (ROR) SCORE IN BREAST CANCER Article Open access 20 March 2024 HIGHLY METASTATIC CLAUDIN-LOW MAMMARY CANCERS CAN ORIGINATE FROM LUMINAL EPITHELIAL CELLS Article Open
access 18 June 2021 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Harvard Medical School,
Boston, 02115, Massachusetts, USA Sam W Lee, Corinne L Reimer & Doreen B Campbell * Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Harvard
Medical School, Boston, 02115, Massachusetts, USA Phil Oh & Jan E Schnitzer Authors * Sam W Lee View author publications You can also search for this author inPubMed Google Scholar *
Corinne L Reimer View author publications You can also search for this author inPubMed Google Scholar * Phil Oh View author publications You can also search for this author inPubMed Google
Scholar * Doreen B Campbell View author publications You can also search for this author inPubMed Google Scholar * Jan E Schnitzer View author publications You can also search for this
author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Lee, S., Reimer, C., Oh, P. _et al._ Tumor cell growth inhibition by
caveolin re-expression in human breast cancer cells. _Oncogene_ 16, 1391–1397 (1998). https://doi.org/10.1038/sj.onc.1201661 Download citation * Received: 05 September 1997 * Revised: 16
October 1997 * Accepted: 17 October 1997 * Published: 31 March 1998 * Issue Date: 19 March 1998 * DOI: https://doi.org/10.1038/sj.onc.1201661 SHARE THIS ARTICLE Anyone you share the
following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer
Nature SharedIt content-sharing initiative KEYWORDS * caveolin * breast cancer * cell cycle * growth inhibition * p53
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