Anupam Agarwal | VA Birmingham Health Care | Veterans Affairs

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Staff Physician, Birmingham VA Health Care System Professor & Director, Division of Nephrology, Executive Vice Dean, UAB School of Medicine

Dr. Agarwal’s research program has provided critical insights regarding the protective nature and significance of heme oxygenase-1 (HO-1) in acute kidney injury (AKI), and the molecular

regulation of the human HO-1 gene. His research efforts include three main areas. (i) His laboratory is studying the molecular regulation of the human HO-1 gene in renal and vascular injury.

Studies have identified key regulatory regions in the human HO-1 gene that mediate induction in response to stimuli such as heme, cytokines, nitric oxide and growth factors. (ii) The

functional significance of HO-1 gene expression is also being evaluated in animal models of acute kidney injury and chronic kidney disease using knockout and cell specific HO-1 expression

(e.g. proximal tubules, myeloid cells). Single cell and single nucleus RNA sequencing studies are being performed to elucidate the cell specific transcriptomic response to AKI. (iii) His

laboratory is also exploring the role of lymphangiogenesis in the pathogenesis of AKI and AKI to CKD.