The cost of long COVID | The Week

_The mysterious constellation of pervasive symptoms has struck millions, and no one can say how long they'll last. Here's everything you need to know:_ HOW MANY PEOPLE ARE

AFFECTED? The CDC and states do not track long COVID cases, so there are no hard numbers, but numerous studies indicate the problem runs deep and wide. A University of Washington study found

30 percent of people who had COVID were still experiencing symptoms after six months; a study by Imperial College London showed almost 15 percent reported three or more symptoms after 12

weeks. Early research indicates between 10 and 30 percent of people who get COVID-19 may face long-term issues. More than 42 million Americans are known to have tested positive for COVID,

and the real total is undoubtedly much higher. So even at the low-end estimate of 10 percent, that means millions of people in the U.S. and the world are "long-haulers," facing

chronic symptoms that can impair their ability to work, exercise, or lead a normal life. Doctors who treat long COVID patients say the costs of both of their future care and lost

productivity could be staggering. "I don't think anyone truly understands the magnitude of this," said Denyse Lutchmansingh, who oversees the Post-COVID-19 Recovery Program at

Yale–New Haven Hospital. "The majority of my patients are in the prime of their work lives, and they're debilitated." SUBSCRIBE TO THE WEEK Escape your echo chamber. Get the

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inbox. WHAT ARE THE SYMPTOMS OF LONG COVID? Literally hundreds of symptoms have been reported. Among the most common are nerve and muscle pain, persistent fatigue, breathing difficulties,

heart palpitations, loss of smell and taste, and gastrointestinal distress. Issues plaguing post-COVID patients range from impaired metabolic function and kidney damage to blood-clotting

problems and menstrual changes. The virus "can affect nearly every organ system," said Ziyad Al-Aly, who studies long-haul patients in the Department of Veterans Affairs health

system. Then there are neurological symptoms, which can be the most debilitating. They include sleep disorders, dizziness, numbness in limbs, anxiety, and brain fog marked by confusion,

memory loss, and inability to concentrate. The worst cases "really look like dementia," said Jördis Frommhold, leader of a German study of long COVID, who cites patients as young

as 18 who "can't form sentences." Cassandra Hernandez, a 38-year-old nurse in San Antonio, went from working on her master's degree to forgetting "how to use a

fork" and struggling to read at a fifth-grade level. "It's embarrassing," she said. WHAT CAUSES THESE PROBLEMS? There are several leading theories. One is that

they're caused by fragments or reserves of the virus that linger in the body. Another possible cause is persistent inflammation or damage wrought by the initial infection, affecting

blood vessels, nerve pathways, or other areas of the body. The dominant theory is that long COVID is an autoimmune disease triggered by infection by an unfamiliar virus, in which

victims' revved-up immune systems continue to attack healthy tissue after the initial infection is gone. Or it could be a combination of these factors. Whatever the cause, long COVID

mirrors other mysterious, chronic illnesses triggered by viral and bacterial infections. Among them is myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), cases of which have been

linked to outbreaks of SARS, Ebola, and other viruses. There are no known markers for who will develop long COVID, which affects many people with no previous health issues — and many whose

initial infections were mild or asymptomatic. DO LONG COVID PATIENTS IMPROVE? The range is broad. Some patients largely return to their old selves within three or four months. Many show

meaningful improvement but have lingering issues. But some remain significantly impaired after a year or more, and struggle to hold jobs. "A lot of us can't afford our medications

or groceries, and quite a few of us are going homeless," said Amanda Finley, a Kansas City archaeologist who founded a Facebook discussion group for long-haulers after suffering

persistent symptoms including brain fog, heart palpitations, fatigue, and shortness of breath. Treatment generally involves managing symptoms through physical therapy, cognitive exercises,

and other treatments. "It's a long process, and people need to make a lot of behavioral and life adjustments," said David Putrino, a rehabilitation specialist who treats long

COVID patients at New York's Mount Sinai Hospital. WHAT CAN BE DONE? In February, the National Institutes of Health launched a $1.2 billion initiative to study the causes and treatment

of long COVID. The American Medical Association and CDC have launched initiatives to educate doctors about identifying and treating the disorder. And across the country, hospitals have

established dozens of integrated clinics dedicated to long COVID, where specialists in various areas are studying the syndrome and refining treatments. "Our clinical model is constantly

evolving as we learn more from our patients," said Yale's Lutchmansingh. Experts warn that we've only begun to reckon with the social and financial costs. "We're

going to need resources for many years to come to deal with these patients," said Putrino. LONG COVID AND THE VACCINATED Do vaccines affect the odds of developing long COVID? Evidence

is emerging that vaccination significantly reduces the chances of lingering symptoms, but that some vaccinated people who get breakthrough infections do in fact become long-haulers. In a

small Israeli study, 19 percent of people with breakthrough infections had continuing symptoms at six weeks, and long COVID clinics in the U.S. say that some of their newer cases are

vaccinated people. It's still unclear to researchers how vaccination affects these lingering symptoms; are they milder, and will they resolve more quickly? Some doctors believe that by

lessening the severity of infection, vaccines will lower the odds of long COVID — and a new British study of 1.2 million adults found fully vaccinated people cut in half their odds of having

symptoms four weeks after falling ill. Some experts predict the prevalence of long COVID will fall as our immune systems become increasingly familiar with the virus through vaccinations,

boosters, and natural exposures. But Zijian Chen, medical director of Mount Sinai's Center for Post-COVID Care, says this is only an educated guess. "It's too early to

tell," he said. _This article was first published in the latest issue of _The Week _magazine. If you want to read more like it, you can try six risk-free issues of the magazine

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