300 years of anti-vaxx delusion | thearticle

Daniel Johnson’s reflections on the continuing importance of vaccination against Covid-19, and the problem of the “militant or indifferent” anti-vaxxers  (_TheArticle_ 26 July ), were timely

in more ways than one. In his recent book, _How To Make a Vaccine: An essential guide for COVID-19 & Beyond_, Dr John Rhodes celebrates the 300th anniversary of the first well-recorded

inoculation against smallpox in Britain in August 1721. At the time smallpox was killing up to 400,000 people in Europe every year, including a grandchild of King George I. The story begins

in Constantinople with the wife of the British Ambassador to the court of the Ottoman Sultan. Once a beauty, Lady Mary Wortley Montagu was disfigured by smallpox. She survived to become an

advocate of inoculation, or as she called it “ingrafting”, a practice performed on the Sultan’s wives. Lady Mary’s son was successfully inoculated against smallpox in 1718. On her return to

London, a grand promotional event for the inoculation of her daughter was organised, with royal court physicians and the King’s physician, Sir Hans Sloane, in attendance. The then Princess

of Wales, Caroline of Ansbach (later Queen Caroline as wife of George II) was well read in the science of the day. She instigated an experiment with the aim of protecting her own children.

Six prisoners due to be hanged in Newgate were offered their lives and freedom if they volunteered as guinea-pigs to test the safety and effectiveness of inoculation, or as it was also

known, _variolation_. With celebrity endorsement from London’s good and great, this became a high profile event which Fellows of the Royal Society and some 25 members of the College of

Physicians came to observe. In charge was the Scottish physician Charles Maitland, a former embassy physician in Constantinople, where he had learned the technique. What followed was not for

the faint-hearted. Maitland made an incision into in an arm and a leg of each convict and then inserted material from the pustules of an infected person. He had to repeat the procedure as

not enough local reaction could be detected. One of the condemned received the material up the nose. A 19-year old girl who had been inoculated was later exposed to a child smallpox victim

and proved to be immune. All six were given a royal pardon and walked free a month later. Public opinion about inoculation was divided and, as it is today, politicised: the Whigs at court

justified the experiment on utilitarian grounds, while the Tories opposed it with the argument that physicians should not play God. The anti-vaxx movement in Britain had begun. Doctors in

Asia had been playing God and evoking opposition for many years. Rhodes quotes the Chinese emperor, _K’ang-hsi_ in the late 1600s: “The method of inoculation having been brought to light

during my reign, I had it used upon you, my sons and daughters,” he wrote. “In the beginning when I had it tested on one or two people, some older person taxed me with extravagance, and

spoke very strongly against inoculation. The courage which I summoned up to insist on its practice has saved the lives and health of millions of men”. The next big step, from inoculation to

vaccination, came courtesy of a Gloucestershire milkmaid, Sarah Nelmes, who caught cowpox from a cow called Blossom. It’s the better known story of two rural physicians, Edward Jenner and

John Fewster, proving that pathogens administered in a weakened form could protect against a more virulent variant. Result: many millions of lives saved. Blossom’s hide hangs on the library

wall of St. George’s Medical School a bovine equivalent of Jeremy Bentham’s stuffed hide displayed in University College London. But there is a lot more to Rhodes’s informative book than

some captivating medical history. He is at his most instructive when teasing out the complexities of the human immune system, a little army of interactive defenders against foreign

intrusion, each with its own task: surveillance cells patrolling, helper T-cells, killer T-cells, B-cells which have daughter cells that produce the antibodies we’ve all heard about,

regulatory T-cells that shut down the immune response once the pathogen is defeated, memory B-cells that, I imagine, must trigger the amplified response from a booster dose of vaccine, and

memory T-cells. I wish the word _awesome_ hadn’t been voided of all meaning. The immune system is simply awesome. Though it can and does make mistakes. _How To Make a Vaccine _is an

important contribution to the genre of science popularisation. It is clearly written, but asks a lot of a reader without any biological or scientific background. This is not because it is

aimed primarily at a scientific audience, but because it is narrating and explaining the intricate complexity of the immune system. There were well over two hundred different Covid vaccines

at different stages of development as Rhodes was writing. They fall into eight distinctive categories, depending on what part of the virus biochemistry is targeted and how: inactivated or

attenuated forms of the virus, its DNA or messenger RNA or its protein configuration, for example. This is good news, as variant mutations are unlikely to counter the effectiveness of all

available vaccine categories, and currently deployed vaccines are still achieving much higher levels of immunity than flu vaccines, which vary between 40-60 per cent effectiveness.

Opposition to protective measures against viruses and bacteria has a long history. Andrew Wakefield’s spurious claim in 1998 that the combined vaccination against measles, mumps and rubella,

MMR, was linked to autism is the direct antecedent to current resistance. The history indicates that a minority of the public will always be prone to making bad decisions about how best to

look after their – and others’ – children or their own health.  And this will inevitably create public health problems. The scientific progress presented in this book is, in many ways,

comforting. It puts flesh on the bones of “following the science”. Anti-vaxxers, especially those addicted to conspiracy theories, should read this book and ask themselves how the medical

profession, with their Hippocratic Oath, has sustained a cunning conspiracy for the last three hundred years — and yet managed to save so many lives. They won’t even open it, of course. The

persistence of opposition to vaccination is sad, difficult, obstinate and dangerous. A MESSAGE FROM THEARTICLE _We are the only publication that’s committed to covering every angle. We have

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