Nature reviews neurology - volume 11 issue 6, june 2015
Nature reviews neurology - volume 11 issue 6, june 2015"
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TOWARD STEM CELL-BASED PHENOTYPIC SCREENS FOR NEURODEGENERATIVE DISEASES Despite the increasing prevalence of neurodegenerative diseases in our ageing population, disease-modifying therapies
remain elusive. As the mechanisms underlying neurodegeneration are poorly understood, these diseases are not especially amenable to target-based drug screening strategies. Here, Khurana_ et
al_. present phenotypic screening as an alternative drug discovery approach, and discuss how insights from a simple eukaryote, baker's yeast, are driving research in patient-derived
neurons. * Vikram Khurana * Daniel F. Tardiff * Susan Lindquist
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