Nature cell biology - volume 14 issue 2, february 2012

Nature

Nature cell biology - volume 14 issue 2, february 2012"


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RAS HITCHHIKES ON PDE6Δ Ras GTPases are tethered to cellular membranes by a farnesyl lipid that modifies a carboxy-terminal cysteine. One of the ways Ras traffics between membranes is via


fluid-phase diffusion, suggesting that a cytosolic chaperone might be needed to shield the farnesyl lipid during transport. PDE6δ is now revealed to be a farnesyl-binding chaperone that


facilitates the trafficking and signalling of Ras. * Mark R. Philips


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