Exploring ageing in microgravity

Microgravity accelerates ageing-like changes in cells and tissues. By integrating bioengineering technologies, researchers can uncover pathways to mitigate ageing and develop therapeutic

interventions for age-related diseases both on Earth and in space. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Ratushnyy, A. Y. & Buravkova, L. B. Microgravity effects and aging physiology: similar

changes or common mechanisms? _Biochemistry_ 88, 1763–1777 (2023). Google Scholar  * Takahashi, H., Nakamura, A. & Shimizu, T. Simulated microgravity accelerates aging of human skeletal

muscle myoblasts at the single cell level. _Biochem. Biophys. Res. Commun._ 578, 115–121 (2021). Article  Google Scholar  * ElGindi, M. et al. May the force be with you (or not): the immune

system under microgravity. _Cells_ 10, 1941 (2021). Article  Google Scholar  * Gabel, L. et al. Incomplete recovery of bone strength and trabecular microarchitecture at the distal tibia 1

year after return from long duration spaceflight. _Sci. Rep._ 12, 9446 (2022). Article  Google Scholar  * Smith, J. K. Osteoclasts and microgravity. _Life_ 10, 207 (2020). Article  Google

Scholar  * ElGindi, M. et al. Effects of an aged tissue niche on the immune potency of dendritic cells using simulated microgravity. _npj Aging_ 9, 14 (2023). Article  Google Scholar  *

Crucian, B. et al. Alterations in adaptive immunity persist during long-duration spaceflight. _npj Microgravity_ 1, 15013 (2015). Article  Google Scholar  * Luxton, J. J. et al. Telomere

length dynamics and DNA damage responses associated with long-duration spaceflight. _Cell. Rep._ 33, 108457 (2020). Article  Google Scholar  * Van Ombergen, A. et al. 3D bioprinting in

microgravity: opportunities, challenges, and possible applications in space. _Adv. Healthc. Mater._ 12, e2300443 (2023). Article  Google Scholar  * Mair, D. B. et al. Spaceflight-induced

contractile and mitochondrial dysfunction in an automated heart-on-a-chip platform. _Proc. Natl Acad. Sci. USA_ 121, e2404644121 (2024). Article  Google Scholar  * ElGindi, M. et al. 3D

microenvironment attenuates simulated microgravity-mediated changes in T cell transcriptome. _Cell. Mol. Life Sci._ 79, 508 (2022). Article  Google Scholar  * Ploutz-Snyder, L. et al.

Effects of sex and gender on adaptation to space: musculoskeletal health. _J. Womens Health_ 23, 963–966 (2014). Article  Google Scholar  Download references ACKNOWLEDGEMENTS The authors

acknowledge support from the New York University Abu Dhabi (NYUAD) Faculty Research Fund (AD266). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Laboratory for Immuno Bioengineering Research

and Applications, Division of Engineering, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates Mei ElGindi & Jeremy Teo * Department of Mechanical and Biomedical Engineering,

New York University Tandon School of Engineering, New York, NY, USA Jeremy Teo Authors * Mei ElGindi View author publications You can also search for this author inPubMed Google Scholar *

Jeremy Teo View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Jeremy Teo. ETHICS DECLARATIONS COMPETING INTERESTS The

authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE ElGindi, M., Teo, J. Exploring ageing in microgravity. _Nat Rev

Bioeng_ (2025). https://doi.org/10.1038/s44222-025-00309-2 Download citation * Published: 17 April 2025 * DOI: https://doi.org/10.1038/s44222-025-00309-2 SHARE THIS ARTICLE Anyone you share

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