Technological challenges of biomembrane-coated top-down cancer nanotherapy

Cancer nanotherapy suffers from low-yield delivery that is imposed by tumour pathophysiological barriers. Top-down drug delivery strategies, including exosomes and cell membrane-coated

particles, can improve safety and efficacy owing to the innate biointerfacial properties of these platforms. Here, we discuss the technological challenges that need to be overcome for their

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subscriptions * Read our FAQs * Contact customer support REFERENCES * Mendes, B. B. et al. Nanodelivery of nucleic acids. _Nat. Rev. Methods Primers_ 2, 24 (2022). Article  Google Scholar  *

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Sci._ 18, 1190 (2017). Article  Google Scholar  Download references ACKNOWLEDGEMENTS J.M.J.M.R., J.C. and A.C.P.S. acknowledge the financial support from the Fundacão para a Ciência e a

Tecnologia I.P. (FCT)-Research and Development Project grant PTDC/BTM-MAT/4738/2020. J.C. acknowledges financial support from the European Research Council-ERC Starting Grant 848325. The

authors thank C. Alvarez-Lorenzo and P. Makvandi for their input and critical revision of this article. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * ToxOmics, NOVA Medical School |

Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, Lisboa, Portugal João M. J. M. Ravasco & João Conde * Research Institute for Medicines (iMed.ULisboa), Faculty of

Pharmacy, University of Lisbon, Lisbon, Portugal João M. J. M. Ravasco * Laboratory of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra,

Coimbra, Portugal Ana Cláudia Paiva-Santos * LAQV/REQUIMTE, Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra,

Portugal Ana Cláudia Paiva-Santos Authors * João M. J. M. Ravasco View author publications You can also search for this author inPubMed Google Scholar * Ana Cláudia Paiva-Santos View author

publications You can also search for this author inPubMed Google Scholar * João Conde View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS

J.M.J.M.R., J.C. and A.C.P.S. contributed to the conceptualization, writing, figure drawing and editing of the current manuscript. CORRESPONDING AUTHORS Correspondence to Ana Cláudia

Paiva-Santos or João Conde. ETHICS DECLARATIONS COMPETING INTERESTS J.C. is a co-founder and shareholder of TargTex S.A. The remaining authors declare no competing interests. RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ravasco, J.M.J.M., Paiva-Santos, A.C. & Conde, J. Technological challenges of biomembrane-coated top-down cancer

nanotherapy. _Nat Rev Bioeng_ 1, 156–158 (2023). https://doi.org/10.1038/s44222-022-00008-2 Download citation * Published: 31 January 2023 * Issue Date: March 2023 * DOI:

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