Soluble guanylyl cyclase in platelets keeps atherosclerosis at bay

The contribution of platelets to atherothrombosis is well established. Accumulating genome-wide association studies have revealed several variants of genes encoding molecules along the

nitric oxide (NO)–soluble guanylyl cyclase (sGC)–cyclic guanosine-3′,5′-monophosphate (cGMP) pathway that are associated with increased risk of coronary artery disease; however, the cell

types and functional impact of these risk variants remain poorly understood. Mauersberger et al. now demonstrate that platelet-specific knockout of a transcript encoding sGC increased

atherosclerosis, whereas pharmacological stimulators of sGC reduced lesions via a paracrine effect of angiopoietin-1 on endothelial cell–leukocyte interactions. Access through your

institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12

digital issues and online access to articles $119.00 per year only $9.92 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices

may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support

REFERENCES * Mussbacher, M., Pirabe, A., Brunnthaler, L., Schrottmaier, W. C. & Assinger, A. _Front. Physiol._ 12, 678362 (2021). Article  Google Scholar  * Lievens, D. & von

Hundelshausen, P. _Thromb. Haemost._ 106, 827–838 (2011). Article  CAS  Google Scholar  * Muhlestein, J. B. _Thromb. Haemost._ 103, 71–82 (2010). Article  CAS  Google Scholar  * Massberg, S.

et al. _J. Exp. Med._ 196, 887–896 (2002). Article  CAS  Google Scholar  * Sim, J. Y. _Korean J. Anesthesiol._ 58, 4–14 (2010). Article  CAS  Google Scholar  * Searles, C. D. _Congest.

Heart Fail._ 8, 142–155 (2002). Article  CAS  Google Scholar  * Consortium, C. A. D. et al. _Nat. Genet._ 45, 25–33 (2013). Article  Google Scholar  * Wobst, J. et al. _Basic Res. Cardiol._

111, 51 (2016). Article  Google Scholar  * Mauersberger, C. et al. _Nat. Cardiovasc. Res._ https://doi.org/10.1038/s44161-022-00175-w (2022). Article  Google Scholar  * Dangel, O. et al. _J.

Thromb. Haemost._ 8, 1343–1352 (2010). Article  CAS  Google Scholar  * Segura-Puimedon, M. et al. _Am. J. Pathol._ 186, 2220–2231 (2016). Article  CAS  Google Scholar  * Tsou, C. Y. et al.

_Acta Physiol._ 210, 799–810 (2014). Article  CAS  Google Scholar  * Zhang, G. et al. _Blood_ 118, 3670–3679 (2011). Article  CAS  Google Scholar  * Kessler, T. et al. _Circulation_ 136,

476–489 (2017). Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS Supported by the US National Institutes of Health (HL115141, HL134849, HL148207, HL148355, HL153356 to

M.W.F.) and the American Heart Association (18SFRN33900144 and 20SFRN35200163 to M.W.F.). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Medicine, Cardiovascular Division,

Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA Anurag Jamaiyar, Jingshu Chen & Mark W. Feinberg Authors * Anurag Jamaiyar View author publications You can also

search for this author inPubMed Google Scholar * Jingshu Chen View author publications You can also search for this author inPubMed Google Scholar * Mark W. Feinberg View author publications

You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Mark W. Feinberg. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing

interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Jamaiyar, A., Chen, J. & Feinberg, M.W. Soluble guanylyl cyclase in platelets keeps

atherosclerosis at bay. _Nat Cardiovasc Res_ 1, 1124–1126 (2022). https://doi.org/10.1038/s44161-022-00188-5 Download citation * Published: 12 December 2022 * Issue Date: December 2022 *

DOI: https://doi.org/10.1038/s44161-022-00188-5 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is

not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative